KIF18A Antibody, Biotin conjugated
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中文名稱：KIF18A兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA847753LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) KIF18A Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：AU024633 antibody; B130001M12Rik antibody; DKFZp434G2226 antibody; KI18A_HUMAN antibody; KIF 18A antibody; KIF18A antibody; kinesin family member 18A antibody; Kinesin like protein KIF18A antibody; Kinesin-like protein KIF18A antibody; Marrow stromal KIF18A antibody; MGC27627 antibody; MS KIF18A antibody; MS-KIF18A antibody; RGD1561740 antibody; RP23 206C1.1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Kinesin-like protein KIF18A protein (176-279AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression.
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基因功能參考文獻：
- High KIF18A expression is associated with invasion and metastasis of hepatocellular carcinoma. PMID: 29466986
- Low post translational modifications of KIF18A protein is associated with neoplasms. PMID: 28209915
- KIF18a role in microtubule assembly PMID: 26912793
- Cdk1-mediated inhibitory phosphorylation of Kif18A promotes chromosome oscillations in early metaphase. PP1 induces metaphase plate thinning by directly dephosphorylating Kif18A. PMID: 25048371
- Confocal microscopy shows that cells expressing SUMO-resistant Kif18A display a compromised dissociation of BubR1 from kinetochores after anaphase onset. PMID: 25884224
- data support a model in which microtubule-attenuating kinesins are molecularly "tuned" to control the dynamics of specific subsets of spindle microtubules PMID: 25208566
- a biomarker for hepatocellular carcinoma diagnosis and an independent predictor of overall survival PMID: 25431949
- that the human mitotic kinesin-8, KIF18A, directly interacts with PP1gamma through a conserved RVxF motif PMID: 25281536
- the motion of yeast (Kip3) and human (Kif18A) kinesin-8s PMID: 23746518
- Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex. PMID: 23288039
- Kif18A (kinesin-8) attenuates centromere movement by directly promoting microtubule pausing in a concentration- dependent manner. PMID: 22595673
- there is a mutual regulation of kinetochore MT plus-end dynamics and Kif18A accumulation, which may contribute to the highly regulated and ordered changes in kinetochore spindle microtubule dynamics during chromosome congression and oscillation PMID: 22104080
- Kif18A controls spindle length independently of its role in chromosome positioning. This is mediated by an ATP-independent spindle microtubule (MT) binding site at C-terminal end of the Kif18A tail that has a strong affinity for MTs in vitro and in cells. PMID: 21885282
- The heightened processivity of Kif18A, conferred by its tail domain, thus promotes concentration of Kif18A at K-MT plus ends, where it suppresses their dynamics to control chromosome movements. PMID: 21884977
- Kif18A overexpression is associated with colorectal cancer progression. PMID: 21213216
- Kinesin (KIF18A) can be potentially used as a blood biomarker to identify asbestosis patients at risk of developing lung cancer. PMID: 21231887
- High Kif18A is associated with breast carcinogenesis. PMID: 20595236
- The kinesin-8 Kif18A dampens microtubule plus-end dynamics. PMID: 20153196
- Kif18A is a dual-functional kinesin and a key component of chromosome congression. PMID: 17346968
- Kif18A regulates kinetochore microtubule dynamics to control mitotic chromosome positioning. PMID: 18267093
- The current study sheds light on MS-KIF18A a microtubule-dependent kinesin and adds insights on the post-translational modifications that potentially control the protein cellular distribution and its co-association with cytoskeletal proteins. PMID: 18680169
- Studies strongly suggest that chromosome congression defects as the result of KIF18A depletion is at least in part mediated through destabilizing kinetochore CENP-E. PMID: 19625775
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亞細胞定位：Cell projection, ruffle. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
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蛋白家族：TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family
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數據庫鏈接：
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