IL31RA
白細(xì)胞介素31受體α（IL31RA），又稱IL-31Rα或CRL3，是介導(dǎo)細(xì)胞因子IL-31功能的核心蛋白。它與輔助亞基OSMRβ結(jié)合形成完整受體復(fù)合物，主要分布于皮膚感覺神經(jīng)元和免疫細(xì)胞表面。當(dāng)IL-31與其結(jié)合時，會觸發(fā)強(qiáng)烈的瘙癢感知并促進(jìn)炎癥介質(zhì)釋放，這一現(xiàn)象在特應(yīng)性皮炎患者的病灶皮膚中尤為顯著，其過度激活可導(dǎo)致慢性瘙癢和表皮屏障損傷。IL31RA在結(jié)節(jié)性癢疹、慢性蕁麻疹等疾病中異常高表達(dá)，并與神經(jīng)免疫交互失調(diào)密切相關(guān)。基于此靶點(diǎn)開發(fā)的單抗藥物nemolizumab已取得突破，全球多中心試驗顯示其能快速緩解頑固性瘙癢，降低患者抓撓頻率，2022年在日本獲批用于特應(yīng)性皮炎治療。目前該藥物正拓展至慢性腎病相關(guān)性瘙癢等新適應(yīng)癥，為IL-31信號異常相關(guān)疾病提供了精準(zhǔn)干預(yù)策略。
熱銷產(chǎn)品
IL31RA Antibody (CSB-PA854162ESR2HU)
驗證數(shù)據(jù)
Western blot
All lanes: IL31RA antibody at 1.45μg/ml + Mouse kidney tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 83, 87, 75, 42, 78, 71, 59, 67, 64, 70, 85 kDa
Observed band size: 83 kDa
Human Interleukin-31 receptor subunit alpha(IL31RA) ELISA kit (CSB-EL011654HU)
驗證數(shù)據(jù)
貨號：CSB-EL011654HU
規(guī)格：96T/48T
靈敏度：1.56 pg/mL
檢測范圍：6.25 pg/mL-400 pg/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
IL31RA Antibodies
IL31RA for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA004737 | IL31RA Antibody | Human | WB, ELISA |
| CSB-PA796040 | IL31RA Antibody | Human | ELISA,IHC |
| CSB-PA107902 | IL31RA Antibody | Human | ELISA,IHC |
| CSB-PA125161 | IL31RA Antibody | Human | ELISA,WB,IHC |
| CSB-PA854162ESR1HU | IL31RA Antibody | Human | ELISA, IHC |
| CSB-PA854162ESR2HU | IL31RA Antibody | Human, Mouse | ELISA, WB |
IL31RA Proteins
IL31RA Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP854162HU CSB-EP854162HU CSB-BP854162HU CSB-MP854162HU CSB-EP854162HU-B |
Recombinant Human Interleukin-31 receptor subunit alpha (IL31RA), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL31RA ELISA Kit
IL31RA ELISA Kit for Homo sapiens (Human)
| 產(chǎn)品貨號 | 產(chǎn)品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL011654HU | Human Interleukin-31 receptor subunit alpha(IL31RA) ELISA kit | serum, plasma, tissue homogenates | 1.56 pg/mL |
