FPS1
FPS1，即鐵死亡抑制蛋白1，別名Ferroptosis-suppressor-protein 1。它是一種黃素蛋白，由德國發育遺傳學研究所和維爾茨堡大學的研究人員發現，FSP1能夠作為一種谷胱甘肽非依賴性鐵死亡抑制因子。FSP1的作用機制涉及到使用NAD(P)H催化泛醌（CoQ10）的再生，泛醇作為還原形式捕獲介導脂質過氧化作用的脂質過氧自由基，從而抑制鐵死亡。FSP1的藥理靶向作用與GPX4抑制劑可產生協同作用，引發鐵死亡。在生物學上，FSP1作為獨立的并行系統存在，與GPX4和谷胱甘肽（GSH）協同作用來抑制磷脂過氧化和鐵死亡，對于了解鐵死亡的病理生理作用以及如何將其用于癌癥治療具有重要意義。
熱銷產品
Recombinant Human Farnesyl pyrophosphate synthase (FDPS) (CSB-EP008563HU)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
FDPS Recombinant Monoclonal Antibody (CSB-RA029525A0HU)
驗證數據
Overlay Peak curve showing HepG2 cells stained with CSB-RA029525A0HU (red line) at 1:50. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
FPS1 Antibodies
FPS1 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA008563GA01HU | FDPS Antibody | Human,Mouse,Rat | ELISA,WB |
| CSB-PA008563LA01HU | FDPS Antibody | Human | ELISA, WB, IHC, IP |
| CSB-PA008563LB01HU | FDPS Antibody, HRP conjugated | Human | ELISA |
| CSB-PA008563LC01HU | FDPS Antibody, FITC conjugated | Human | |
| CSB-PA008563LD01HU | FDPS Antibody, Biotin conjugated | Human | ELISA |
| CSB-RA029525A0HU | FDPS Recombinant Monoclonal Antibody | Human | ELISA, FC |
FPS1 Proteins
FPS1 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP008563HU CSB-BP008563HU CSB-MP008563HU CSB-EP008563HU-B |
Recombinant Human Farnesyl pyrophosphate synthase (FDPS) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP008563HU | Recombinant Human Farnesyl pyrophosphate synthase (FDPS) | E.coli |
