FCRL6
FcRL6 通過其與其他Fc受體同源物和FcγRI的同源性進行鑒定，盡管它保留了一些對結合IgG很重要的殘基，但未檢測到表達FcRL6的細胞與可溶性或熱聚集的人IgM或IgG的結合。這表明該分子不是Fc受體，并且其胞外域的配體未定義。FcRL6的細胞質尾部募集SHP-2，表明該蛋白在通過配體誘導的交聯調節細胞活化的某些方面具有功能。SHP-2已被證明在幾種抑制性受體的信號通路中充當負調節劑。然而，SHP-2在許多生長因子受體和細胞因子受體信號通路中也充當正調節劑，例如促進 Ras-ERK活化，導致增殖和存活。FcRL6募集SHP-2對NK細胞和CD8+T細胞功能的影響有待進一步研究。除了確定的典型信號基序外，FcRL6在蛋白質的C末端還包含一個重復的CxEVxC基序。雖然我們在其他蛋白質中沒有發現這種基序的先例，但重復的半胱氨酸和酸性殘基讓人想起在含鋅指或環指的蛋白質中發現的Zn2+結合位點。
FCRL6 Antibodies
FCRL6 for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA718779LA01HU | FCRL6 Antibody | Human | ELISA |
| CSB-PA718779LB01HU | FCRL6 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA718779LC01HU | FCRL6 Antibody, FITC conjugated | Human | |
| CSB-PA718779LD01HU | FCRL6 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA718779ESR2HU | FCRL6 Antibody | Human | ELISA, WB, IHC |
FCRL6 Proteins
FCRL6 Proteins for Mus musculus (Mouse)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP008559MO1 CSB-EP008559MO1 CSB-BP008559MO1 CSB-MP008559MO1 CSB-EP008559MO1-B |
Recombinant Mouse Fc receptor-like protein 6 (Fcrl6), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF008559MO | Recombinant Mouse Fc receptor-like protein 6 (Fcrl6) | in vitro E.coli expression system |
FCRL6 Proteins for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP718779HU | Recombinant Human Fc receptor-like protein 6 (FCRL6), partial | Yeast |
| CSB-EP718779HU | Recombinant Human Fc receptor-like protein 6 (FCRL6), partial | E.coli |
| CSB-BP718779HU | Recombinant Human Fc receptor-like protein 6 (FCRL6), partial | Baculovirus |
| CSB-MP718779HU | Recombinant Human Fc receptor-like protein 6 (FCRL6), partial | Mammalian cell |
