CLDN6

CLDN6位于染色體16p3.3，分子量大約20-40kDa。Claudins成員之間具有相似的結(jié)構(gòu)，每個(gè)Claudin分子有4個(gè)跨膜結(jié)構(gòu)域，2個(gè)細(xì)胞外環(huán)和2條胞內(nèi)尾區(qū)。CLDN6擁有一個(gè)C端的PDZ結(jié)合位點(diǎn)，使得緊密連接蛋白能與細(xì)胞內(nèi)某些蛋白發(fā)生相互作用關(guān)系，在細(xì)胞連接及上皮組織通透性等方面均可發(fā)揮重要作用

越來(lái)越多的研究表明，CLDN6異常表達(dá)可參與乳腺癌，卵巢癌，宮頸癌，胃癌，肺癌等多種惡性腫瘤發(fā)生及發(fā)展過(guò)程。CLDN6作為細(xì)胞骨架的形成和細(xì)胞信號(hào)通路調(diào)節(jié)的重要分子，可影響細(xì)胞的生長(zhǎng)進(jìn)程，這為腫瘤的診斷和干預(yù)提供了新的方向。目前，多款針對(duì)CLDN6的藥物已處于臨床和臨床前階段，用于多種腫瘤的治療。

CUSABIO-哺乳包膜VIPs平臺(tái)成功開發(fā)CLDN6全長(zhǎng)跨膜蛋白（4次跨膜），展示了完整生物活性。

熱銷產(chǎn)品

Recombinant Human Claudin-6 (CLDN6)-VLPs (Active) (CSB-MP005508HU(A4))

驗(yàn)證數(shù)據(jù)

CSB-MP005508HU(A4) is detected by Mouse anti-6*His monoclonal antibody.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CLDN6 at 10 μg/ml can bind Anti-CLDN6/9 recombinant antibody (CSB-RA005508MA1HU), the EC₅₀ is 1.501-2.035 ng/mL

The presence of VLP-like structures was confirmed by TEM

Human CLDN6 Monoclonal Antibody (CSB-RA005508MA1HU) captured on Protein A Chip can bind Human CLDN6 Full Length VLP Protein with an affinity constant of 6.58 nM as detected by MetaSPR Assay (WeSPR^TM 200).

The purity of VLPs was greater than 95% as determined by SEC-HPLC

CLDN6/9 Monoclonal Antibody (CSB-RA005508MA1HU)

驗(yàn)證數(shù)據(jù)

The Binding Activity of Huamn CLDN6 with Anti-CLDN6/9 recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN6 (CSB-MP005508HU(A4)) at 10 μg/mL can bind Anti-CLDN6/9 recombinant antibody, the EC₅₀ is 1.501-2.035 ng/mL.

The Binding Activity of Human CLDN9 with Anti-CLDN6/9 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN9 (CSB-MP005511HU) at 10 μg/mL can bind Anti-CLDN6/9 recombinant antibody, the EC₅₀ is 24.93-35.47 ng/mL.

Untransfected HEK293T cells surface (green line) and transfected Human CLDN6 HEK293T stable cells surface (red line) were stained with anti-CLDN6/9 recombinant antibody (2μg/1*10⁶cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

Untransfected MC38 cells (green line) and transfected Human CLDN9 MC38 stable cells (red line) were stained with anti-CLDN6/9 antibody (2μg/1*10⁶cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

Untransfected CHO-K1*10⁶cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

Untransfected MC38 cells (green line) and transfected Human CLDN6 MC38 stable cells (red line) were stained with anti-CLDN6/9 antibody (2μg/1*10⁶cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

The Binding Activity of Macaca fascicularis CLDN6 with Anti-CLDN6/9 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis CLDN6(CSB-MP6148GKN) at 5 μg/mL can bind Anti-CLDN6/9 recombinant antibody. The EC₅₀ is 4.186-6.635 ng/mL.
The VLPs (CSB-MP3838) is negative control.

The Binding Activity of Human CLDN6 with Anti-CLDN6/9 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN6 (CSB-MP005508HU(A5)-D) at 2 μg/mL can bind Anti-CLDN6/9 recombinant antibody. The EC₅₀ is 1.243-2.426 ng/mL.

The Binding Activity of Human CLDN9 with Anti-CLDN6/9 Recombinant Antibody
Activity：Measured by its binding ability in a functional ELISA. Immobilized Human CLDN9 (CSB-MP005511HU-D) at 2 μg/ml on an Nickel Coated plate can bind Anti-CLDN6/9 recombinant antibody. The EC₅₀?is 2.812-3.524 ng/mL.

The Binding Activity of Mouse cldn6 with Anti-CLDN6/9 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse cldn6(CSB-MP3347MO) at 5 μg/mL can bind Anti-CLDN6/9 recombinant antibody. The EC₅₀ is 4.027-6.270 ng/mL.

CLDN6 Recombinant Monoclonal Antibody (CSB-RA005508MA2HU)

驗(yàn)證數(shù)據(jù)

The Binding Activity of Human CLDN6 with Anti-CLDN6 recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN6 (CSB-MP005508HU(A4)) at 10 μg/mL can bind Anti-CLDN6 recombinant antibody. The EC₅₀ is 2.033-2.415 ng/mL. The VLPs (CSB-MP3838) is negative control.

Untransfected HEK-293T cells (green line) and transfected Human CLDN6 HEK-293T stable cells (red line) were stained with anti-CLDN6 antibody (2μg/1*10⁶cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

Untransfected MC38 cells (green line) and transfected Human CLDN6 MC38 stable cells (red line) were stained with anti-CLDN6 antibody (2μg/1*10⁶cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

CLDN6 Antibody

CLDN6 Protein

CLDN6 Antibodies

CLDN6 for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	種屬反應(yīng)性	應(yīng)用類型
CSB-PA207788	Phospho-CLDN6 (Tyr219) Antibody	Human,Mouse	ELISA,WB
CSB-PA263732	CLDN6 Antibody	Human	ELISA,WB,IHC,IF
CSB-PA001673	CLDN6 Antibody	Human	WB, IHC, IF, ELISA
CSB-PA070220	Phospho-CLDN6 (Y219) Antibody	Human,Mouse	WB, IHC, ELISA
CSB-PA070221	CLDN6 Antibody	Human,Mouse	IHC, ELISA
CSB-PA005508LA01HU	CLDN6 Antibody	Human	ELISA, IHC, IF
CSB-PA005508LB01HU	CLDN6 Antibody, HRP conjugated	Human	ELISA
CSB-RA005508MA1HU	CLDN6/9 Monoclonal Antibody	Human, Macaca fascicularis, Mouse	ELISA, FC

CLDN6 Proteins

CLDN6 Proteins for Homo sapiens (Human)

產(chǎn)品貨號(hào)	產(chǎn)品名稱	來(lái)源
CSB-YP005508HU1 CSB-EP005508HU1 CSB-BP005508HU1 CSB-EP005508HU1-B	Recombinant Human Claudin-6 (CLDN6), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-MP005508HU(A4)	Recombinant Human Claudin-6 (CLDN6)-VLPs (Active)	Mammalian cell
CSB-MP005508HU(A4)f4	Recombinant Human Claudin-6 (CLDN6)-VLPs, Fluorescent (Active)	Mammalian cell
CSB-MP005508HU(A5)-D	Recombinant Human Claudin-6 (CLDN6), partial-Detergent (Active)	Mammalian cell