AIMP2
AIMP2，全稱為氨酰tRNA合成酶復(fù)合物相互作用多功能蛋白2，是一種參與蛋白質(zhì)生物合成的關(guān)鍵蛋白。別名JTV-1、P38等。AIMP2蛋白與多種疾病的發(fā)生發(fā)展密切相關(guān)，如肺癌、神經(jīng)元疾病等。在肺癌中，AIMP2蛋白的變體AIMP2-DX2被發(fā)現(xiàn)可以促進(jìn)腫瘤生成并抑制炎性標(biāo)記物Cox-2的表達(dá)。此外，AIMP2-DX2在正常細(xì)胞中的表達(dá)導(dǎo)致細(xì)胞癌變，而抑制AIMP2-DX2的形成則抑制癌細(xì)胞的生長(zhǎng)，從而達(dá)到治療癌癥的效果。在神經(jīng)元疾病方面，AIMP2蛋白也被發(fā)現(xiàn)可以治療神經(jīng)元疾病，如阿爾茨海默病、帕金森氏病等。
針對(duì)AIMP2蛋白的藥物研發(fā)也在不斷進(jìn)展中。例如，韓國(guó)巴斯德研究所InheeChoi課題組在Journal of Enzyme Inhibition and Medicinal Chemistry雜志上報(bào)道了首個(gè)基于已知AIMP2-DX2抑制劑BC-DXI-495設(shè)計(jì)的，可靶向AIMP2-DX2的高效蛋白降解劑化合物45。該化合物在體外實(shí)驗(yàn)中可高效抑制A549細(xì)胞中高表達(dá)的AIMP2-DX2，且對(duì)AIMP2蛋白本身沒有任何影響，顯示出良好的選擇性。
熱銷產(chǎn)品
驗(yàn)證數(shù)據(jù)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
AIMP2 Antibody (CSB-PA819153ESR1HU)
驗(yàn)證數(shù)據(jù)
Western blot
All lanes: AIMP2 antibody at 5μg/ml
Lane 1: Hela whole cell lysate
Lane 2: HepG2 whole cell lysate
Lane 3: K562 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 35 kDa
Observed band size: 35 kDa
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA819153ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA819153ESR1HU at dilution of 1:100
AIMP2 Antibodies
AIMP2 for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 種屬反應(yīng)性 | 應(yīng)用類型 |
|---|---|---|---|
| CSB-PA819153ESR1HU | AIMP2 Antibody | Human | ELISA, WB, IHC |
| CSB-PA151818 | AIMP2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA289421 | AIMP2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
| CSB-PA904906 | AIMP2 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
AIMP2 Proteins
AIMP2 Proteins for Homo sapiens (Human)
| 產(chǎn)品貨號(hào) | 產(chǎn)品名稱 | 來源 |
|---|---|---|
| CSB-YP618761HU CSB-BP618761HU CSB-MP618761HU CSB-EP618761HU-B |
Recombinant Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP618761HU | Recombinant Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) | E.coli |
