AIMP2 Antibody
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中文名稱：AIMP2兔多克隆抗體
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貨號：CSB-PA819153ESR1HU
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規(guī)格：￥440
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圖片：
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Western blot
All lanes: AIMP2 antibody at 5μg/ml
Lane 1: Hela whole cell lysate
Lane 2: HepG2 whole cell lysate
Lane 3: K562 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 35 kDa
Observed band size: 35 kDa -
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA819153ESR1HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA819153ESR1HU at dilution of 1:100
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) AIMP2 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：Aimp2 antibody; AIMP2_HUMAN antibody; Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 antibody; Aminoacyl tRNA synthetase complex interacting multifunctional protein 2 antibody; ARS interacting multi functional protein 2 antibody; JTV 1 antibody; JTV 1 protein antibody; JTV1 antibody; JTV1 gene antibody; Multisynthase complex auxiliary component p38 antibody; Multisynthetase complex auxiliary component p38 antibody; P38 antibody; PRO0992 antibody; Protein JTV 1 antibody; Protein JTV-1 antibody; tRNA SYNTHETASE COFACTOR p38 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 protein (141-320AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:200-1:1000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Required for assembly and stability of the aminoacyl-tRNA synthase complex. Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation. Blocks MDM2-mediated ubiquitination and degradation of p53/TP53. Functions as a proapoptotic factor.
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基因功能參考文獻：
- AIMP2-DX2 plays an important role in the regulation of Nasopharyngeal carcinoma. PMID: 29854811
- Homozygosity for a nonsense variant in AIMP2 is associated with a progressive neurodevelopmental disorder with microcephaly, seizures, and spastic quadriparesis. PMID: 29215095
- These findings provide new mechanistic insights into the role of VPS35 in the regulation of AIMP2 levels and cell death. PMID: 28383562
- AIMP2 underexpression is associated with lung neoplasms. PMID: 27197155
- our findings show how DX2 promotes lung cancer progression and how its activity may be thwarted as a strategy to treat patients with lung cancers exhibiting elevated DX2 levels PMID: 27302160
- These data indicate monomer-dimer equilibrium of AIMP2-DX2 in solution. These results form the basis for the structure-function study of oncogenic AIMP2-DX2. PMID: 28185908
- analysis of the heterotetrameric complex structure of the glutathione transferase (GST) domains shared among the four MSC components, methionyl-tRNA synthetase (MRS), glutaminyl-prolyl-tRNA synthetase (EPRS), AIMP2 and AIMP3 PMID: 26472928
- Ubiquitin and SUMO compete for the same lysine (K242) on influenza A virus M1 and the interaction of viral NS2 with human AIMP2 facilitates the switch of the M1 modification from ubiquitination to SUMOylation, thus increasing viral replication. PMID: 25320310
- These findings suggested that, although excessive accumulation of oxidative DNA damage was present in LSCs, the relatively decreased phosphorylation of p38 might help leukemic cells escape senescence and apoptosis. PMID: 22684553
- Transgeneic overexpression of AIMP2 led to a selective, age-dependent, progressive loss of dopaminergic neurons. PMID: 23974709
- The tumorigenic activity of AIMP2-DX2 can be controlled by the small chemical BC-DXI01, which can selectively suppress the AIMP2-DX2 mRNA transcript. PMID: 23815603
- AIMP2-DX2, a splicing variant of tumor suppressor AIMP2, can be a therapeutic target to control chemoresistant epithelial ovarian cancer . PMID: 22532625
- downregulation of AIMP2 lacking exon 2 (AIMP2-DX2), expressed in different cancer cells, suppressed the epidermal growth factor receptor/mitogen activated protein kinase signaling pathway PMID: 22562359
- ribozyme could selectively deliver the activity of a suicide gene into the AIMP2-DX2 RNA expressing lung cancer cells and thereby specifically and effectively retard the growth of the cancer cells with prodrug treatment. PMID: 22285955
- a splicing variant of AIMP2 lacking exon 2 (AIMP2-DX2) is highly expressed by alternative splicing in human lung cancer cells and patient's tissues PMID: 21483803
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亞細(xì)胞定位：Cytoplasm, cytosol. Nucleus.
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