Recombinant Mouse DnaJ homolog subfamily C member 15 (Dnajc15)

in vitro E.coli expression system

中文名稱：

小鼠Dnajc15重組蛋白
貨號：

CSB-CF762363MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

基因名：

Dnajc15
Uniprot No.：

Q78YY6
別名：

Dnajc15; Dnajd1; DnaJ homolog subfamily C member 15
種屬：

Mus musculus (Mouse)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-149
氨基酸序列

MATGGGVTSREGLRYAEYLPPSAQRSDADIDHTAGRRLLAVGLGVAAVAFAGRYAFQIWK PLEQVITATARKISSPSFSSYYKGGFEQKMSKREASLILGVSPSAGKAKIRTAHKRIMIL NHPDKGGSPYLASKINEAKDLLEASSKAN
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

功能：

Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9. Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP.
基因功能參考文獻(xiàn)：
1. In vivo treatment with an inhibitor of MCJ expression protects liver from acetaminophen-induced liver injury in mouse model at a time when N-acetylcysteine, the standard therapy, has no efficacy. Acetaminophen-induced liver injury progresses through the central participation of MCJ in vitro and in vivo. PMID: 29233977
2. DNAJC15 localizes at the mitochondrial inner membrane, where it interacts preferentially with complex I of the electron transfer chain.DnaJC15 functions as a negative regulator of mitochondrial membrane potential and ATP production. PMID: 23530063
亞細(xì)胞定位：

Mitochondrion inner membrane; Single-pass membrane protein.
組織特異性：

Expressed at high levels in liver, heart, at moderate levels in kidney and, at very low levels, in lung (at protein level). High expression levels in testis. Highly expressed in CD8+ T-cells, but barely detectable in CD4+ T-cells (at protein level). Almos
數(shù)據(jù)庫鏈接：

KEGG: mmu:66148

STRING: 10090.ENSMUSP00000022590

UniGene: Mm.248046