Recombinant Canine distemper virus Hemagglutinin glycoprotein (H)

in vitro E.coli expression system

中文名稱：

Recombinant Canine distemper virus Hemagglutinin glycoprotein(H)
貨號：

CSB-CF338584CCQ
說明書：

MSDS Datasheet
規(guī)格：
來源：

in vitro E.coli expression system
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

基因名：

H
Uniprot No.：

P24306
別名：

H; Hemagglutinin glycoprotein
種屬：

Canine distemper virus (strain Onderstepoort) (CDV)
蛋白長度：

full length protein
表達(dá)區(qū)域：

1-604
氨基酸序列

MLPYQDKVGAFYKDNARANSTKLSLVTEGHGGRRPPYLLFVLLILLVGILALLAITGVRF HQVSTSNMEFSRLLKEDMEKSEAVHHQVIDVLTPLFKIIGDEIGLRLPQKLNEIKQFILQ KTNFFNPNREFDFRDLHWCINPPSTVKVNFTNYCESIGIRKAIASAANPILLSALSGGRG DIFPPHRCSGATTSVGKVFPLSVSLSMSLISRTSEVINMLTAISDGVYGKTYLLVPDDIE REFDTREIRVFEIGFIKRWLNDMPLLQTTNYMVLPKNSKAKVCTIAVGELTLASLCVEES TVLLYHDSSGSQDGILVVTLGIFWATPMDHIEEVIPVAHPSMKKIHITNHRGFIKDSIAT WMVPALASEKQEEQKGCLESACQRKTYPMCNQASWEPFGGRQLPSYGRLTLPLDASVDLQ LNISFTYGPVILNGDGMDYYESPLLNSGWLTIPPKDGTISGLINKAGRGDQFTVLPHVLT FAPRESSGNCYLPIQTSQIRDRDVLIESNIVVLPTQSIRYVIATYDISRSDHAIVYYVYD PIRTISYTHPFRLTTKGRPDFLRIECFVWDDNLWCHQFYRFEADIANSTTSVENLVRIRF SCNR
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標(biāo)簽：

N-terminal 10xHis-tagged
產(chǎn)品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產(chǎn)品評價

靶點詳情

功能：

Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. The cellular receptor might be SLAM, and may explain the lymphotropism of the virus.
基因功能參考文獻：
1. These findings support a mode of binding between the Canine Distemper Virus attachment protein and the V domain of CD150/SLAM and suggest a major role of the SLAM residue E123 in triggering the fusion machinery. PMID: 26608324
2. The data suggest that H binds the F globular head domain sideways. PMID: 25355896
3. Different N-linked glycosylation sites were identified in the F and H genes of the six isolates from the prototype vaccine strain. PMID: 23624803
4. These results suggest that a restricted region on one side of canine distemper virus H protein contains distinct and overlapping sites that control functional interaction with multiple receptors. PMID: 21849439
5. These data show that three key residues in the virulent canine distemper virus A75/17 H protein (Y525, D526, and R529) control SLAM-binding activity without drastically modulating protein surface expression or SLAM-independent F triggering. PMID: 20631152
6. Data show that recombinant viruses expressing N-glycan-deficient H proteins no longer cause disease, though their immunosuppressive capacities are retained, indicating that reduced N glycosylation affects attenuation without affecting immunosuppression. PMID: 20042514
7. at least three different CDV genotypes, distantly related to the vaccine strains, Onderstepoort-like (America-1 genotype), are currently circulating in breeding foxes, raccoon dogs and minks in China, and that the genotype Asia-1 is predominant PMID: 19647380
8. susceptibility to CD9 antibodies segregates with the H protein; it was determined that the complete extracellular domain, including the predicted stem structure and globular head domain of the CDV-H protein mediates the effect PMID: 16690928
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亞細(xì)胞定位：

Virion membrane; Single-pass type II membrane protein. Host cell membrane; Single-pass type II membrane protein.
蛋白家族：

Paramyxoviruses hemagglutinin-neuraminidase family, Non-sialidase subfamily
數(shù)據(jù)庫鏈接：

KEGG: vg:1489792