Recombinant Canine distemper virus Hemagglutinin glycoprotein (H), partial

中文名稱：

Recombinant Canine distemper virus Hemagglutinin glycoprotein(H) ,partial
貨號：

CSB-YP338584CCQ1
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

Recombinant Canine distemper virus Hemagglutinin glycoprotein(H) ,partial
貨號：

CSB-EP338584CCQ1
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

Recombinant Canine distemper virus Hemagglutinin glycoprotein(H) ,partial
貨號：

CSB-EP338584CCQ1-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Canine distemper virus Hemagglutinin glycoprotein(H) ,partial
貨號：

CSB-BP338584CCQ1
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Canine distemper virus Hemagglutinin glycoprotein(H) ,partial
貨號：

CSB-MP338584CCQ1
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

H
Uniprot No.：

P24306
別名：

H; Hemagglutinin glycoprotein
種屬：

Canine distemper virus (strain Onderstepoort) (CDV)
蛋白長度：

partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

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Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. The cellular receptor might be SLAM, and may explain the lymphotropism of the virus.
基因功能參考文獻：
1. These findings support a mode of binding between the Canine Distemper Virus attachment protein and the V domain of CD150/SLAM and suggest a major role of the SLAM residue E123 in triggering the fusion machinery. PMID: 26608324
2. The data suggest that H binds the F globular head domain sideways. PMID: 25355896
3. Different N-linked glycosylation sites were identified in the F and H genes of the six isolates from the prototype vaccine strain. PMID: 23624803
4. These results suggest that a restricted region on one side of canine distemper virus H protein contains distinct and overlapping sites that control functional interaction with multiple receptors. PMID: 21849439
5. These data show that three key residues in the virulent canine distemper virus A75/17 H protein (Y525, D526, and R529) control SLAM-binding activity without drastically modulating protein surface expression or SLAM-independent F triggering. PMID: 20631152
6. Data show that recombinant viruses expressing N-glycan-deficient H proteins no longer cause disease, though their immunosuppressive capacities are retained, indicating that reduced N glycosylation affects attenuation without affecting immunosuppression. PMID: 20042514
7. at least three different CDV genotypes, distantly related to the vaccine strains, Onderstepoort-like (America-1 genotype), are currently circulating in breeding foxes, raccoon dogs and minks in China, and that the genotype Asia-1 is predominant PMID: 19647380
8. susceptibility to CD9 antibodies segregates with the H protein; it was determined that the complete extracellular domain, including the predicted stem structure and globular head domain of the CDV-H protein mediates the effect PMID: 16690928
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亞細胞定位：

Virion membrane; Single-pass type II membrane protein. Host cell membrane; Single-pass type II membrane protein.
蛋白家族：

Paramyxoviruses hemagglutinin-neuraminidase family, Non-sialidase subfamily
數據庫鏈接：

KEGG: vg:1489792