Recombinant Mouse Cytosolic acyl coenzyme A thioester hydrolase (Acot7)

中文名稱：

Recombinant Mouse Cytosolic acyl coenzyme A thioester hydrolase(Acot7)
貨號(hào)：

CSB-YP835557MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Cytosolic acyl coenzyme A thioester hydrolase(Acot7)
貨號(hào)：

CSB-EP835557MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Cytosolic acyl coenzyme A thioester hydrolase(Acot7)
貨號(hào)：

CSB-EP835557MO-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Cytosolic acyl coenzyme A thioester hydrolase(Acot7)
貨號(hào)：

CSB-BP835557MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Cytosolic acyl coenzyme A thioester hydrolase(Acot7)
貨號(hào)：

CSB-MP835557MO
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Acot7
Uniprot No.：

Q91V12
別名：

Acot7; BachCytosolic acyl coenzyme A thioester hydrolase; EC 3.1.2.2; Acyl-CoA thioesterase 7; Brain acyl-CoA hydrolase; BACH; CTE-IIa; CTE-II; Long chain acyl-CoA thioester hydrolase
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

full length protein
表達(dá)區(qū)域：

1-381
氨基酸序列

MKLLVGTLRL WEVGRQVAFS SLTPGQECSG LRKTFWAAMR AVRTRADHQK LGHCVTMGRI MRPDDANVAG NVHGGTILKM IEEAGAIIST RHCNSQNGER CVAALARVER TDFLSPMCIG EVAHVSAEIT YTSKHSVEVQ VHVMSENILT GTKKLTNKAT LWYVPLSLKN VDKVLEVPPI VYLRQEQEEE GRKRYEAQKL ERMETKWRNG DIVQPVLNPE PNTVSYSQSS LIHLVGPSDC TLHGFVHGGV TMKLMDEVAG IVAARHCKTN IVTASVDAIN FHDKIRKGCV ITISGRMTFT SNKSMEIEVL VDADPVVDNS QKRYRAASAF FTYVSLNQEG KPMPVPQLVP ETEDEKKRFE EGKGRYLQMK AKRQGHTEPQ P
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Preferentially hydrolyzes palmitoyl-CoA, but has a broad specificity acting on other fatty acyl-CoAs with chain-lengths of C8-C18. May play an important physiological function in brain.
基因功能參考文獻(xiàn)：
1. downstream effects of LPS-induced induction of ACOT7 and its role in inflammatory settings in myeloid cells PMID: 28416579
2. Data (including data from studies in transgenic mice) suggest that up-regulation of Acot7 expression in clonal beta-cells impairs insulin secretion in response to glucose plus free fatty acids; expression of Acot7 is ubiquitous across tissues but relatively silenced/disallowed in pancreatic beta cells. PMID: 26861785
3. ACOT7 may be involved in dietary intake-associated responses in fatty acid metabolism in mesenteric lymph nodes. PMID: 23649344
4. ACOT7 counterregulates fatty acid metabolism in neurons and protects against neurotoxicity. PMID: 23459938
5. mBACH cDNA encoded a 338-AA pp >95% identical to human and rat homologs. mBACH was distributed throughboth central and peripheral cell body and neurites. Another 50-kDa pp made from mBACH mRNA used different in-frame ATGs as initiation codon. PMID: 11834298
6. Acot7 gene is expressed as multiple isoforms in a tissue-specific manner; expression in tissues other than brain and testis is likely to play important roles in fatty acid metabolism. PMID: 17514357
7. The structural basis for recruitmment of tandem domains in Acot7 is demonstrated and its role in inflammation presented. PMID: 17563367
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亞細(xì)胞定位：

[Isoform A]: Cytoplasm, cytosol.; [Isoform D]: Cytoplasm, cytosol.
組織特異性：

Widely expressed with highest levels in brain. High levels also found in thymus, large intestine and testis. Negligible in muscle and adipose tissue. In the central and peripheral nervous systems, displays a predominantly neuronal localization with highes
數(shù)據(jù)庫鏈接：

KEGG: mmu:70025

STRING: 10090.ENSMUSP00000129121

UniGene: Mm.296191