Recombinant Human YY1-associated protein 1 (YY1AP1)

中文名稱：

人YY1AP1重組蛋白
貨號：

CSB-YP884488HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人YY1AP1重組蛋白
貨號：

CSB-EP884488HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人YY1AP1重組蛋白
貨號：

CSB-EP884488HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人YY1AP1重組蛋白
貨號：

CSB-BP884488HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人YY1AP1重組蛋白
貨號：

CSB-MP884488HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

YY1AP1
Uniprot No.：

Q9H869
別名：

FLJ10875; FLJ13914; GRNG; HCCA1; HCCA2; Hepatocellular carcinoma susceptibility protein; Hepatocellular carcinoma-associated protein 2; OTTHUMP00000033475; OTTHUMP00000033476; OTTHUMP00000200831; OTTHUMP00000200832; OTTHUMP00000200833; OTTHUMP00000200836; YAP; YY1-associated protein 1; YY1AP; YY1AP1; YYAP1_HUMAN
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-796
氨基酸序列

MEEEASRSAA ATNPGSRLTR WPPPDKREGS AVDPGKRRSL AATPSSSLPC TLIALGLRHE KEANELMEDL FETFQDEMGF SNMEDDGPEE EERVAEPQAN FNTPQALRFE ELLANLLNEQ HQIAKELFEQ LKMKKPSAKQ QKEVEKVKPQ CKEVHQTLIL DPAQRKRLQQ QMQQHVQLLT QIHLLATCNP NLNPEASSTR ICLKELGTFA QSSIALHHQY NPKFQTLFQP CNLMGAMQLI EDFSTHVSID CSPHKTVKKT ANEFPCLPKQ VAWILATSKV FMYPELLPVC SLKAKNPQDK ILFTKAEDNK YLLTCKTARQ LTVRIKNLNM NRAPDNIIKF YKKTKQLPVL GKCCEEIQPH QWKPPIEREE HRLPFWLKAS LPSIQEELRH MADGAREVGN MTGTTEINSD QGLEKDNSEL GSETRYPLLL PKGVVLKLKP VADRFPKKAW RQKRSSVLKP LLIQPSPSLQ PSFNPGKTPA QSTHSEAPPS KMVLRIPHPI QPATVLQTVP GVPPLGVSGG ESFESPAALP AMPPEARTSF PLSESQTLLS SAPVPKVMMP SPASSMFRKP YVRRRPSKRR GARAFRCIKP APVIHPASVI FTVPATTVKI VSLGGGCNMI QPVNAAVAQS PQTIPIATLL VNPTSFPCPL NQPLVASSVS PLIVSGNSVN LPIPSTPEDK AHMNVDIACA VADGENAFQG LEPKLEPQEL SPLSATVFPK VEHSPGPPPV DKQCQEGLSE NSAYRWTVVK TEEGRQALEP LPQGIQESLN NSSPGDLEEV VKMEPEDATE EISGFL
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Associates with the INO80 chromatin remodeling complex, which is responsible for transcriptional regulation, DNA repair, and replication. Enhances transcription activation by YY1. Plays a role in cell cycle regulation.
基因功能參考文獻：
1. Data indicate WW-binding protein 2 (WBP2) as an important co-factor of YY1 associated protein 1 (YAP) that enhances YAP/TEAD-mediated gene transcription. PMID: 28332498
2. Loss-of-Function Mutations in YY1AP1 Lead to Grange Syndrome and a Fibromuscular Dysplasia-Like Vascular Disease. PMID: 27939641
3. YY1AP1 may serve as a key molecular target for EpCAM(+) AFP(+) HCC subtype PMID: 25597408
4. human liver cancer associated gene PMID: 11856496
5. YY1AP is a novel co-activator of YY1 PMID: 14744866
6. HCCA2 may play a novel role in cell cycle regulation. PMID: 17541814
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相關疾病：

Grange syndrome (GRNG)
亞細胞定位：

Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus.
組織特異性：

Ubiquitous. Detected in small intestine, skeletal muscle, lung, pancreas, brain, stomach, spleen, colon and heart. Detected at very low levels in healthy liver. Highly expressed in most liver carcinomas.
數據庫鏈接：

HGNC: 30935

OMIM: 602531

KEGG: hsa:55249

STRING: 9606.ENSP00000357323

UniGene: Hs.584927