Recombinant Human Tropomyosin alpha-3 chain (TPM3)

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中文名稱：

人TPM3重組蛋白
貨號：

CSB-EP024106HU
說明書：

MSDS Datasheet
規格：

￥1344
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 85% as determined by SDS-PAGE.
基因名：

TPM3
Uniprot No.：

P06753
別名：

Alpha tropomyosin 3; Alpha tropomyosin slow skeletal; CFTD; Cytoskeletal tropomyosin TM30; FLJ41118; gamma TM; Gamma tropomyosin; Gamma-tropomyosin; Heat stable cytoskeletal protein 30 kDa; hscp30; hTM30nm; hTM5; hTMnm; MGC102590; MGC14582; MGC3261; MGC72094; NEM1; OK/SW-cl.5; OTTHUMP00000034019; OTTHUMP00000034171; OTTHUMP00000034172; TM 5; TM-5; TM3; TM30; TM30nm; TM5; Tm5NM; Tpm 5; TPM3; TPM3/NTRK1 FUSION GENE, INCLUDED; TPM3_HUMAN; Tpm5; TPMsk3; TRK; TRK ONCOGENE, INCLUDED; Trop 5; Tropomyosin 3; Tropomyosin 3 gamma; Tropomyosin 5; Tropomyosin alpha 3 chain; Tropomyosin alpha-3 chain; Tropomyosin gamma; Tropomyosin-3; Tropomyosin-5
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
來源：

E.coli
分子量：

59.8kDa
表達區域：

2-285aa
氨基酸序列

MEAIKKKMQMLKLDKENALDRAEQAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAADAEAEVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRALKDEEKMELQEIQLKEAKHIAEEADRKYEEVARKLVIIEGDLERTEERAELAESKCSELEEELKNVTNNLKSLEAQAEKYSQKEDKYEEEIKILTDKLKEAETRAEFAERSVAKLEKTIDDLEDELYAQKLKYKAISEELDHALNDMTSI
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal GST-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

Tris-based buffer,50% glycerol
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

3-7 business days
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
基因功能參考文獻：
1. Analysis of the residual, resected tumor identified a chromoplectic TPM3-ALK rearrangement that involved many other known oncogenes and was confirmed by rtPCR. PMID: 27742657
2. expression levels of tropomyosin 3 (TPM3) were higher in stage III ESCC tissue compared with stage I (P<0.05). The findings of the present study identified twelve proteins, which are closely associated with ESCC invasion and metastasis, apoptosis and cell signal transduction. PMID: 28138712
3. Dominant mutations in TPM3, encoding alpha-tropomyosinslow, cause a congenital myopathy characterized by generalized muscle weakness. Here, we used a multidisciplinary approach to investigate the mechanism of muscle dysfunction in 12 TPM3-myopathy patients. PMID: 26307083
4. This work expands the phenotypic spectrum of TPM3-related disease and provides insights into the pathophysiological mechanisms of the actin-tropomyosin complex PMID: 26418456
5. Western blot showed phosphorylation of ALK, ERK1/2, and STAT3 in cells transfected with TPM3-ALK. Coiled-coil structure of TPM3 contributes to the transforming ability of the TPM3-ALK fusion protein, and longer TPM3 region leads to higher dimer formation. PMID: 25596129
6. DATA show that tropomyosin 3 protein (TPM3) plays a critical role in the progression of gliomas. PMID: 24913705
7. study reports on a three-generation family with cap myopathy caused by a novel heterozygous mutation in TPM3 PMID: 24239060
8. TPM3-R167H mutations decreased cooperative thin filament activation in combination with reductions in the myosin cross-bridge number and force production. PMID: 22798622
9. TPM3 is an interacting partner of granulin-epithelin precursor and may play an important role in hepatocarcinogenesis. PMID: 22792281
10. investigation of biomarkers for early diagnosis of endometriosis: Data suggest that TPM3, stomatin-like protein 2, and tropomodulin 3 are autoantigens present in blood of women with endometriosis; immunodominant epitopes were identified. PMID: 22158085
11. study reports clinico-pathological and electrophysiological features of 2 unrelated cases with heterozygous TPM3 mutation; cases highlight neuromuscular transmission defect in congenital myopathy with fibre type disproportion secondary to TPM3 mutations PMID: 20951040
12. High TPM3-PDGFRB fusion protein expression is associated with chronic eosinophilic leukemia. PMID: 21072821
13. variation in the tropomyosin isoform composition of microfilaments provides a mechanism to generate functionally distinct filament populations PMID: 21036167
14. TPM3 mutations are involved in fiber size disproportion in congenital myotonic dystrophy PMID: 20179953
15. the clinical, myopathological and muscle MRI findings in a German family with autosomal dominant nemaline myopathy due to a novel pathogenic TPM3 mutation PMID: 20012312
16. Overexpression of TPM3 activates Snail mediated EMT, which will repress E-cadherin expression and that it confers migration or invasion potentials to HCC cells during hepatocarcinogenesis. PMID: 20356415
17. Conditional TPM3-ALK and NPM-ALK transgenic mice develop reversible ALK-positive early B-cell lymphoma/leukemia. PMID: 20223922
18. Mutations in TPM3 were identified in 6 out of 13 patients with Congenital fiber type disproportion, as well as in one case of nemaline myopathy. PMID: 19953533
19. cloned and sequenced a novel nonmuscle tropomyosin (hTM) isoform, TC22, which is strongly associated with colonic neoplasia and carcinoma PMID: 12105844
20. A mutation converting the stop codon to a serine and a second splicing mutation predicted to prevent inclusion of skeletal muscle exon IX were found associated with nemaline myopathy PMID: 12196661
21. De novo missense mutation in a constitutively expressed exon of the slow alpha-tropomyosin gene TPM3 associated with an atypical, sporadic case of nemaline myopathy. PMID: 12467750
22. tropomyosin isoforms regulate neuronal size and shape PMID: 15888546
23. second pedigree with autosomal dominant nemaline myopathy caused by TPM3 mutation(Arg167His). PMID: 17376686
24. Mutation of TPM3 is the most common cause of congenital fiber type disproportion reported to date. PMID: 18300303
25. The mutation reported here is the first deletion to be identified in TPM3, and it is likely to be a founder mutation in the Turkish population. PMID: 18382475
26. TTC9A acts as a chaperone protein to facilitate the function of tropomyosins (including Tm5NM-1) in stabilizing microfilament and it may play a role in cancer cell invasion and metastasis PMID: 18699990
27. We report a TPM3 mutation in one of the original cases of cap disease. PMID: 19487656
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相關疾病：

Nemaline myopathy 1 (NEM1); Myopathy, congenital, with fiber-type disproportion (CFTD); Cap myopathy 1 (CAPM1)
亞細胞定位：

Cytoplasm, cytoskeleton.
蛋白家族：

Tropomyosin family
數據庫鏈接：

HGNC: 12012

OMIM: 164970

KEGG: hsa:7170

STRING: 9606.ENSP00000357516

UniGene: Hs.535581