TPM3 Antibody, FITC conjugated
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中文名稱：TPM3兔多克隆抗體, FITC偶聯
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貨號：CSB-PA024106LC01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) TPM3 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：Alpha tropomyosin 3 antibody; Alpha tropomyosin slow skeletal antibody; CFTD antibody; Cytoskeletal tropomyosin TM30 antibody; FLJ41118 antibody; gamma TM antibody; Gamma tropomyosin antibody; Gamma-tropomyosin antibody; Heat stable cytoskeletal protein 30 kDa antibody; hscp30 antibody; hTM30nm antibody; hTM5 antibody; hTMnm antibody; MGC102590 antibody; MGC14582 antibody; MGC3261 antibody; MGC72094 antibody; NEM1 antibody; OK/SW-cl.5 antibody; OTTHUMP00000034019 antibody; OTTHUMP00000034171 antibody; OTTHUMP00000034172 antibody; TM 5 antibody; TM-5 antibody; TM3 antibody; TM30 antibody; TM30nm antibody; TM5 antibody; Tm5NM antibody; Tpm 5 antibody; TPM3 antibody; TPM3/NTRK1 FUSION GENE, INCLUDED antibody; TPM3_HUMAN antibody; Tpm5 antibody; TPMsk3 antibody; TRK antibody; TRK ONCOGENE, INCLUDED antibody; Trop 5 antibody; Tropomyosin 3 antibody; Tropomyosin 3 gamma antibody; Tropomyosin 5 antibody; Tropomyosin alpha 3 chain antibody; Tropomyosin alpha-3 chain antibody; Tropomyosin gamma antibody; Tropomyosin-3 antibody; Tropomyosin-5 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Tropomyosin alpha-3 chain protein (18-224AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
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基因功能參考文獻：
- Analysis of the residual, resected tumor identified a chromoplectic TPM3-ALK rearrangement that involved many other known oncogenes and was confirmed by rtPCR. PMID: 27742657
- expression levels of tropomyosin 3 (TPM3) were higher in stage III ESCC tissue compared with stage I (P<0.05). The findings of the present study identified twelve proteins, which are closely associated with ESCC invasion and metastasis, apoptosis and cell signal transduction. PMID: 28138712
- Dominant mutations in TPM3, encoding alpha-tropomyosinslow, cause a congenital myopathy characterized by generalized muscle weakness. Here, we used a multidisciplinary approach to investigate the mechanism of muscle dysfunction in 12 TPM3-myopathy patients. PMID: 26307083
- This work expands the phenotypic spectrum of TPM3-related disease and provides insights into the pathophysiological mechanisms of the actin-tropomyosin complex PMID: 26418456
- Western blot showed phosphorylation of ALK, ERK1/2, and STAT3 in cells transfected with TPM3-ALK. Coiled-coil structure of TPM3 contributes to the transforming ability of the TPM3-ALK fusion protein, and longer TPM3 region leads to higher dimer formation. PMID: 25596129
- DATA show that tropomyosin 3 protein (TPM3) plays a critical role in the progression of gliomas. PMID: 24913705
- study reports on a three-generation family with cap myopathy caused by a novel heterozygous mutation in TPM3 PMID: 24239060
- TPM3-R167H mutations decreased cooperative thin filament activation in combination with reductions in the myosin cross-bridge number and force production. PMID: 22798622
- TPM3 is an interacting partner of granulin-epithelin precursor and may play an important role in hepatocarcinogenesis. PMID: 22792281
- investigation of biomarkers for early diagnosis of endometriosis: Data suggest that TPM3, stomatin-like protein 2, and tropomodulin 3 are autoantigens present in blood of women with endometriosis; immunodominant epitopes were identified. PMID: 22158085
- study reports clinico-pathological and electrophysiological features of 2 unrelated cases with heterozygous TPM3 mutation; cases highlight neuromuscular transmission defect in congenital myopathy with fibre type disproportion secondary to TPM3 mutations PMID: 20951040
- High TPM3-PDGFRB fusion protein expression is associated with chronic eosinophilic leukemia. PMID: 21072821
- variation in the tropomyosin isoform composition of microfilaments provides a mechanism to generate functionally distinct filament populations PMID: 21036167
- TPM3 mutations are involved in fiber size disproportion in congenital myotonic dystrophy PMID: 20179953
- the clinical, myopathological and muscle MRI findings in a German family with autosomal dominant nemaline myopathy due to a novel pathogenic TPM3 mutation PMID: 20012312
- Overexpression of TPM3 activates Snail mediated EMT, which will repress E-cadherin expression and that it confers migration or invasion potentials to HCC cells during hepatocarcinogenesis. PMID: 20356415
- Conditional TPM3-ALK and NPM-ALK transgenic mice develop reversible ALK-positive early B-cell lymphoma/leukemia. PMID: 20223922
- Mutations in TPM3 were identified in 6 out of 13 patients with Congenital fiber type disproportion, as well as in one case of nemaline myopathy. PMID: 19953533
- cloned and sequenced a novel nonmuscle tropomyosin (hTM) isoform, TC22, which is strongly associated with colonic neoplasia and carcinoma PMID: 12105844
- A mutation converting the stop codon to a serine and a second splicing mutation predicted to prevent inclusion of skeletal muscle exon IX were found associated with nemaline myopathy PMID: 12196661
- De novo missense mutation in a constitutively expressed exon of the slow alpha-tropomyosin gene TPM3 associated with an atypical, sporadic case of nemaline myopathy. PMID: 12467750
- tropomyosin isoforms regulate neuronal size and shape PMID: 15888546
- second pedigree with autosomal dominant nemaline myopathy caused by TPM3 mutation(Arg167His). PMID: 17376686
- Mutation of TPM3 is the most common cause of congenital fiber type disproportion reported to date. PMID: 18300303
- The mutation reported here is the first deletion to be identified in TPM3, and it is likely to be a founder mutation in the Turkish population. PMID: 18382475
- TTC9A acts as a chaperone protein to facilitate the function of tropomyosins (including Tm5NM-1) in stabilizing microfilament and it may play a role in cancer cell invasion and metastasis PMID: 18699990
- We report a TPM3 mutation in one of the original cases of cap disease. PMID: 19487656
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相關疾病：Nemaline myopathy 1 (NEM1); Myopathy, congenital, with fiber-type disproportion (CFTD); Cap myopathy 1 (CAPM1)
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亞細胞定位：Cytoplasm, cytoskeleton.
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蛋白家族：Tropomyosin family
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數據庫鏈接：
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