Recombinant Human Transcription factor 20 (TCF20), partial

中文名稱：

人TCF20重組蛋白
貨號：

CSB-YP887024HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人TCF20重組蛋白
貨號：

CSB-EP887024HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人TCF20重組蛋白
貨號：

CSB-EP887024HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人TCF20重組蛋白
貨號：

CSB-BP887024HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人TCF20重組蛋白
貨號：

CSB-MP887024HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

TCF20
Uniprot No.：

Q9UGU0
別名：

TCF20; KIAA0292; SPBP; Transcription factor 20; TCF-20; Nuclear factor SPBP; Protein AR1; Stromelysin-1 PDGF-responsive element-binding protein; SPRE-binding protein
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator.
基因功能參考文獻：
1. Nonsense and one frameshift variant of TCF20 were identified the patients with intellectual disability and postnatal overgrowth. Such de novo variants of TCF20 may represent a novel differential diagnosis in the overgrowth syndrome spectrum. PMID: 27436265
2. mutations in TCF20 are associated with Autism spectrum disorders PMID: 25228304
3. SPBP is a transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62. PMID: 24416372
4. evolutionary conservation of chromatin binding of SPBP and RAI1 PMID: 24205348
5. Study has identified SPBP as a transcriptional coactivator of AR. We also show that Pax6 inhibits SPBP-mediated enhancement of AR activity on the AR target gene probasin promoter, a repression that was partly reversed by increased expression of SPBP. PMID: 21935435
6. SPBP behaves as a repressor of activated ERalpha PMID: 15831449
7. Interaction between SPBP and TopBP1 was found to be mediated by the ePHD domain of SPBP and the BRCT6 domain of TopBP1. PMID: 17913746
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亞細胞定位：

Nucleus.
組織特異性：

Expressed in most tissues, except in ovary and prostate. Isoform 1 is exclusively expressed in brain, heart and testis, and this form predominates in liver and kidney. Isoform 2 predominates in lung.
數據庫鏈接：

HGNC: 11631

OMIM: 603107

KEGG: hsa:6942

STRING: 9606.ENSP00000352463

UniGene: Hs.475018