TCF20 Antibody

中文名稱：

TCF20兔多克隆抗體
貨號：

CSB-PA887024LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA887024LA01HU diluted at 1:300 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA887024LA01HU diluted at 1:300 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TCF20 Polyclonal antibody
Uniprot No.：

Q9UGU0
基因名：

TCF20
別名：

TCF20 antibody; KIAA0292 antibody; SPBP antibody; Transcription factor 20 antibody; TCF-20 antibody; Nuclear factor SPBP antibody; Protein AR1 antibody; Stromelysin-1 PDGF-responsive element-binding protein antibody; SPRE-binding protein antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Transcription factor 20 protein (539-704AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，TCF20 Antibody (CSB-PA887024LA01HU)，的標記方式是Non-conjugated。對于TCF20 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA887024LB01HU	TCF20 Antibody, HRP conjugated	ELISA
FITC	CSB-PA887024LC01HU	TCF20 Antibody, FITC conjugated
Biotin	CSB-PA887024LD01HU	TCF20 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator.
基因功能參考文獻：
1. Nonsense and one frameshift variant of TCF20 were identified the patients with intellectual disability and postnatal overgrowth. Such de novo variants of TCF20 may represent a novel differential diagnosis in the overgrowth syndrome spectrum. PMID: 27436265
2. mutations in TCF20 are associated with Autism spectrum disorders PMID: 25228304
3. SPBP is a transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62. PMID: 24416372
4. evolutionary conservation of chromatin binding of SPBP and RAI1 PMID: 24205348
5. Study has identified SPBP as a transcriptional coactivator of AR. We also show that Pax6 inhibits SPBP-mediated enhancement of AR activity on the AR target gene probasin promoter, a repression that was partly reversed by increased expression of SPBP. PMID: 21935435
6. SPBP behaves as a repressor of activated ERalpha PMID: 15831449
7. Interaction between SPBP and TopBP1 was found to be mediated by the ePHD domain of SPBP and the BRCT6 domain of TopBP1. PMID: 17913746
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亞細胞定位：

Nucleus.
組織特異性：

Expressed in most tissues, except in ovary and prostate. Isoform 1 is exclusively expressed in brain, heart and testis, and this form predominates in liver and kidney. Isoform 2 predominates in lung.
數據庫鏈接：

HGNC: 11631

OMIM: 603107

KEGG: hsa:6942

STRING: 9606.ENSP00000352463

UniGene: Hs.475018

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