Recombinant Human Transcription elongation factor, mitochondrial (TEFM)

中文名稱：

人TEFM重組蛋白
貨號：

CSB-YP857011HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Yeast
其他：

中文名稱：

人TEFM重組蛋白
貨號：

CSB-EP857011HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
其他：

中文名稱：

人TEFM重組蛋白
貨號：

CSB-EP857011HU-B
說明書：

MSDS Datasheet
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人TEFM重組蛋白
貨號：

CSB-BP857011HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

人TEFM重組蛋白
貨號：

CSB-MP857011HU
說明書：

MSDS Datasheet
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

TEFM
Uniprot No.：

Q96QE5
別名：

TEFM; C17orf42; Transcription elongation factor; mitochondrial
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達(dá)區(qū)域：

36-360
氨基酸序列

KSTTP KKITPNVTFC DENAKEPENA LDKLFSSEQQ ASILHVLNTA STKELEAFRL LRGRRSINIV EHRENFGPFQ NLESLMNVPL FKYKSTVQVC NSILCPKTGR EKRKSPENRF LRKLLKPDIE RERLKAVNSI ISIVFGTRRI AWAHLDRKLT VLDWQQSDRW SLMRGIYSSS VYLEEISSII SKMPKADFYV LEKTGLSIQN SSLFPILLHF HIMEAMLYAL LNKTFAQDGQ HQVLSMNRNA VGKHFELMIG DSRTSGKELV KQFLFDSILK ADPRVFFPSD KIVHYRQMFL STELQRVEEL YDSLLQAIAF YELAVFDSQP
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

功能：

Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery.
基因功能參考文獻(xiàn)：
1. Data provide insights into target specificity of TEFM and mechanisms by which it regulates the switch between transcription and replication of mitochondrial DNA. PMID: 29033127
2. Data indicate transcription elongation factor (TEFM) as an essential component of the mitochondrial transcription machinery. PMID: 25690892
3. study found interaction of TEFM with mitochondrial RNA polymerase and nascent transcript prevents generation of replication primers and increases transcription processivity and serves as a molecular switch between replication and transcription, which appear to be mutually exclusive processes in mitochondria PMID: 25635099
4. The TEFM protein is proposed to be a critical component of the transcription apparatus of human mitochondria. PMID: 21278163
亞細(xì)胞定位：

Mitochondrion matrix. Mitochondrion matrix, mitochondrion nucleoid.
蛋白家族：

TEFM family
數(shù)據(jù)庫鏈接：

HGNC: 26223

OMIM: 616422

KEGG: hsa:79736

UniGene: Hs.317340