Recombinant Human Selenocysteine insertion sequence-binding protein 2 (SECISBP2), partial

中文名稱：

人SECISBP2重組蛋白
貨號：

CSB-YP853506HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人SECISBP2重組蛋白
貨號：

CSB-EP853506HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人SECISBP2重組蛋白
貨號：

CSB-EP853506HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人SECISBP2重組蛋白
貨號：

CSB-BP853506HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人SECISBP2重組蛋白
貨號：

CSB-MP853506HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

SECISBP2
Uniprot No.：

Q96T21
別名：

DKFZp686C09169; OTTHUMP00000064929; OTTHUMP00000064930; OTTHUMP00000064931; OTTHUMP00000064932; RP11 89K14.1; SBP 2; SBP2; SEBP2_HUMAN; SECIS binding protein 2; SECIS-binding protein 2; SECISBP 2; SECISBP2; Selenocysteine insertion sequence binding protein 2; Selenocysteine insertion sequence-binding protein 2
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.
基因功能參考文獻：
1. functions as a vital factor in selenoprotein translation and regulates the pro-oxidant/antioxidant balance in trophoblasts PMID: 28623977
2. SBP2 interacts directly with four proteins of the SMN complex and the methylosome core proteins. PMID: 28115638
3. SBP2 makes direct contacts with a discrete region of the human 28S rRNA. PMID: 24850884
4. The patient showed typical symptoms of SBP2 deficiency, and novel compound heterozygous mutations were identified in SBP2 (p.M515fsX563/p.Q79X). PMID: 22247018
5. Selenocysteine insertion sequence (SECIS)-binding protein 2 alters conformational dynamics of residues involved in tRNA accommodation in 80 S ribosomes. PMID: 22308032
6. Describe subjects with compound heterozygous defects in the SECISBP2 gene. These individuals have reduced synthesis of most of the 25 known human selenoproteins, resulting in a complex phenotype. PMID: 21084748
7. Results demonstrate that SECIS-binding protein 2 is required for protection against reactive oxygen species-induced cellular damage and cell survival. PMID: 19803747
8. In addition to identifying key amino acids for SECIS recognition by SBP2, our findings led to the proposal that some of the recognition principles governing the 15.5 kD-U4 snRNA interaction must be similar in the SBP2-SECIS RNA complex PMID: 12403468
9. Oxidative stress induces nuclear accumulation of SBP2 via oxidation of cysteine residues within a redox-sensitive cysteine-rich domain. PMID: 16782878
10. Data suggest that SBP2 is a major determinant in dictating the hierarchy of selenoprotein synthesis via differential selenoprotein mRNA translation and sensitivity to nonsense-mediated decay. PMID: 17846120
11. A report of a complex splicing pattern in the 5'-region of human SECISBP2, wherein at least eight splice variants encode five isoforms with varying N-terminal sequence. PMID: 19004874
12. CUG-BP1 and HuR act as factors that bind to the SBP2 3' UTR, which suggests that TTR-RBPs play a role in the regulation of SBP2 PMID: 19106619
13. Seleniuim is obviously not a limiting factor in the SBP2 deficient individuals when regular daily selenium intake is provided PMID: 19265499
14. ca. 70% of the SBP2 sequence is disordered, whereas the RNA binding domain appears to be folded and functional. PMID: 19467292
15. SBP2 gene mutation producing early arrest in synthesis of full-length molecule. Demonstration that SBP2 isoforms containing all functional domains could be synthesized from three downstream ATGs explains the relatively mild phenotype caused by this defect PMID: 19602558
顯示更多

收起更多
相關疾病：

Abnormal thyroid hormone metabolism (ATHYHM)
亞細胞定位：

[Isoform 1]: Nucleus.; [Isoform 2]: Mitochondrion.
組織特異性：

Expressed at high levels in testis.
數據庫鏈接：

HGNC: 30972

OMIM: 607693

KEGG: hsa:79048

STRING: 9606.ENSP00000364965

UniGene: Hs.59804