SECISBP2 Antibody

說明書

中文名稱：

SECISBP2兔多克隆抗體
貨號：

CSB-PA020962GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q96T21
基因名：

SECISBP2
別名：

DKFZp686C09169 antibody; OTTHUMP00000064929 antibody; OTTHUMP00000064930 antibody; OTTHUMP00000064931 antibody; OTTHUMP00000064932 antibody; RP11 89K14.1 antibody; SBP 2 antibody; SBP2 antibody; SEBP2_HUMAN antibody; SECIS binding protein 2 antibody; SECIS-binding protein 2 antibody; SECISBP 2 antibody; SECISBP2 antibody; Selenocysteine insertion sequence binding protein 2 antibody; Selenocysteine insertion sequence-binding protein 2 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human SECISBP2
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.
基因功能參考文獻：
1. functions as a vital factor in selenoprotein translation and regulates the pro-oxidant/antioxidant balance in trophoblasts PMID: 28623977
2. SBP2 interacts directly with four proteins of the SMN complex and the methylosome core proteins. PMID: 28115638
3. SBP2 makes direct contacts with a discrete region of the human 28S rRNA. PMID: 24850884
4. The patient showed typical symptoms of SBP2 deficiency, and novel compound heterozygous mutations were identified in SBP2 (p.M515fsX563/p.Q79X). PMID: 22247018
5. Selenocysteine insertion sequence (SECIS)-binding protein 2 alters conformational dynamics of residues involved in tRNA accommodation in 80 S ribosomes. PMID: 22308032
6. Describe subjects with compound heterozygous defects in the SECISBP2 gene. These individuals have reduced synthesis of most of the 25 known human selenoproteins, resulting in a complex phenotype. PMID: 21084748
7. Results demonstrate that SECIS-binding protein 2 is required for protection against reactive oxygen species-induced cellular damage and cell survival. PMID: 19803747
8. In addition to identifying key amino acids for SECIS recognition by SBP2, our findings led to the proposal that some of the recognition principles governing the 15.5 kD-U4 snRNA interaction must be similar in the SBP2-SECIS RNA complex PMID: 12403468
9. Oxidative stress induces nuclear accumulation of SBP2 via oxidation of cysteine residues within a redox-sensitive cysteine-rich domain. PMID: 16782878
10. Data suggest that SBP2 is a major determinant in dictating the hierarchy of selenoprotein synthesis via differential selenoprotein mRNA translation and sensitivity to nonsense-mediated decay. PMID: 17846120
11. A report of a complex splicing pattern in the 5'-region of human SECISBP2, wherein at least eight splice variants encode five isoforms with varying N-terminal sequence. PMID: 19004874
12. CUG-BP1 and HuR act as factors that bind to the SBP2 3' UTR, which suggests that TTR-RBPs play a role in the regulation of SBP2 PMID: 19106619
13. Seleniuim is obviously not a limiting factor in the SBP2 deficient individuals when regular daily selenium intake is provided PMID: 19265499
14. ca. 70% of the SBP2 sequence is disordered, whereas the RNA binding domain appears to be folded and functional. PMID: 19467292
15. SBP2 gene mutation producing early arrest in synthesis of full-length molecule. Demonstration that SBP2 isoforms containing all functional domains could be synthesized from three downstream ATGs explains the relatively mild phenotype caused by this defect PMID: 19602558
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相關疾?。?/div>
Abnormal thyroid hormone metabolism (ATHYHM)
亞細胞定位：

[Isoform 1]: Nucleus.; [Isoform 2]: Mitochondrion.
組織特異性：

Expressed at high levels in testis.
數據庫鏈接：

HGNC: 30972

OMIM: 607693

KEGG: hsa:79048

STRING: 9606.ENSP00000364965

UniGene: Hs.59804

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