Recombinant Human Nidogen-2 (NID2), partial

中文名稱：

人NID2重組蛋白
貨號：

CSB-YP614513HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人NID2重組蛋白
貨號：

CSB-EP614513HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人NID2重組蛋白
貨號：

CSB-EP614513HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人NID2重組蛋白
貨號：

CSB-BP614513HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人NID2重組蛋白
貨號：

CSB-MP614513HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

NID2
Uniprot No.：

Q14112
別名：

NID 2; NID-2; Nid2; NID2_HUMAN; Nidogen-2; Nidogen2; Osteonidogen
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions.
基因功能參考文獻：
1. High NID2 methylation is associated with non-small cell lung cancer. PMID: 29970687
2. the serum NID2 levels show significant elevation in the ESCC patients and those with relatively high serum NID2 levels ( 32.6 mu mu g/L) are significantly associated with poor survival outcome compared with those with very low serum NID2 levels (< < 20.0 mu mu g/L). PMID: 29278876
3. Addition of a TWIST1/NID2-based DNA methylation assay adds diagnostic value to urine cytology and the model is sensitive to the classification of equivocal cytology. PMID: 28106542
4. Promoter methylation of NID2 was significantly higher in nasopharyngeal carcinoma and esophageal squamous cell carcinoma cells. NID2 suppresses the EGFR/Akt and integrin/FAK/PLCgamma metastasis-related pathways. PMID: 27793011
5. Knockdown of nidogen-2 reduced SOX9 expression, whereas it up-regulated RUNX2 expression PMID: 26683663
6. The cleavage of nidogen-1 and -2 is partially inhibited in human tumor samples. PMID: 23681936
7. combined methylation analysis of Twist homolog 1 and nidogen-2 genes may be a simple, noninvasive, sensitive, and specific method for detecting cancer cells in urine. PMID: 23682613
8. Decreased nidogen-2 expression is associated with hepatocellular carcinoma PMID: 21815147
9. NID2 promoter hypermethylation is associated with oral cavity squamous cell carcinoma. PMID: 21558411
10. Nidogen-2 is a new biomarker for ovarian cancer which correlates closely with CA125. PMID: 19883638
11. short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin, nidogen-1, fibulin-1 and fibulin-2 PMID: 11733994
12. found to be ubiquitous component of basement membrane zones underneath developing epithelia of most of the major organ systems; may participate in cell biological functions during human development PMID: 12005023
13. Nidogen-2 compensation hypothesis to explain limited phenotype observed following elimination of nidogen-1 gene. PMID: 12475645
14. nidogen-2 is equivalent to nidogen-1 in skin-organotypic coculture, and both can promote the development of a functional basement membrane zone PMID: 17008882
15. CpG islands of both NID1 and NID2 genes are aberrantly methylated in human cancer samples and cancer cell lines. PMID: 17328794
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亞細胞定位：

Secreted, extracellular space, extracellular matrix, basement membrane.
組織特異性：

Heart, placenta and bone. Less in pancreas, kidney and skeletal muscle.
數據庫鏈接：

HGNC: 13389

OMIM: 605399

KEGG: hsa:22795

STRING: 9606.ENSP00000216286

UniGene: Hs.369840