NID2 Antibody
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中文名稱：NID2兔多克隆抗體
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貨號(hào)：CSB-PA015803GA01HU
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規(guī)格：￥3,900
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：NID2
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別名：NID 2 antibody; NID-2 antibody; Nid2 antibody; NID2_HUMAN antibody; Nidogen-2 antibody; Nidogen2 antibody; Osteonidogen antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Human NID2
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA,WB,IHC
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Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions.
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基因功能參考文獻(xiàn)：
- High NID2 methylation is associated with non-small cell lung cancer. PMID: 29970687
- the serum NID2 levels show significant elevation in the ESCC patients and those with relatively high serum NID2 levels ( 32.6 mu mu g/L) are significantly associated with poor survival outcome compared with those with very low serum NID2 levels (< < 20.0 mu mu g/L). PMID: 29278876
- Addition of a TWIST1/NID2-based DNA methylation assay adds diagnostic value to urine cytology and the model is sensitive to the classification of equivocal cytology. PMID: 28106542
- Promoter methylation of NID2 was significantly higher in nasopharyngeal carcinoma and esophageal squamous cell carcinoma cells. NID2 suppresses the EGFR/Akt and integrin/FAK/PLCgamma metastasis-related pathways. PMID: 27793011
- Knockdown of nidogen-2 reduced SOX9 expression, whereas it up-regulated RUNX2 expression PMID: 26683663
- The cleavage of nidogen-1 and -2 is partially inhibited in human tumor samples. PMID: 23681936
- combined methylation analysis of Twist homolog 1 and nidogen-2 genes may be a simple, noninvasive, sensitive, and specific method for detecting cancer cells in urine. PMID: 23682613
- Decreased nidogen-2 expression is associated with hepatocellular carcinoma PMID: 21815147
- NID2 promoter hypermethylation is associated with oral cavity squamous cell carcinoma. PMID: 21558411
- Nidogen-2 is a new biomarker for ovarian cancer which correlates closely with CA125. PMID: 19883638
- short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin, nidogen-1, fibulin-1 and fibulin-2 PMID: 11733994
- found to be ubiquitous component of basement membrane zones underneath developing epithelia of most of the major organ systems; may participate in cell biological functions during human development PMID: 12005023
- Nidogen-2 compensation hypothesis to explain limited phenotype observed following elimination of nidogen-1 gene. PMID: 12475645
- nidogen-2 is equivalent to nidogen-1 in skin-organotypic coculture, and both can promote the development of a functional basement membrane zone PMID: 17008882
- CpG islands of both NID1 and NID2 genes are aberrantly methylated in human cancer samples and cancer cell lines. PMID: 17328794
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亞細(xì)胞定位：Secreted, extracellular space, extracellular matrix, basement membrane.
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組織特異性：Heart, placenta and bone. Less in pancreas, kidney and skeletal muscle.
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數(shù)據(jù)庫(kù)鏈接：
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