Recombinant Human Matrix metalloproteinase-28 (MMP28)

中文名稱：

人MMP28重組蛋白
貨號：

CSB-YP880950HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人MMP28重組蛋白
貨號：

CSB-EP880950HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人MMP28重組蛋白
貨號：

CSB-EP880950HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人MMP28重組蛋白
貨號：

CSB-BP880950HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人MMP28重組蛋白
貨號：

CSB-MP880950HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

MMP28
Uniprot No.：

Q9H239
別名：

Epilysin; Matrix metalloproteinase 28; Matrix metalloproteinase-28; MM 28; MM28; MMP 25; MMP 28; MMP-28; MMP25; MMP28; MMP28_HUMAN
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length of Mature Protein
表達區域：

123-520
氨基酸序列

FAKQGNKW YKQHLSYRLV NWPEHLPEPA VRGAVRAAFQ LWSNVSALEF WEAPATGPAD IRLTFFQGDH NDGLGNAFDG PGGALAHAFL PRRGEAHFDQ DERWSLSRRR GRNLFVVLAH EIGHTLGLTH SPAPRALMAP YYKRLGRDAL LSWDDVLAVQ SLYGKPLGGS VAVQLPGKLF TDFETWDSYS PQGRRPETQG PKYCHSSFDA ITVDRQQQLY IFKGSHFWEV AADGNVSEPR PLQERWVGLP PNIEAAAVSL NDGDFYFFKG GRCWRFRGPK PVWGLPQLCR AGGLPRHPDA ALFFPPLRRL ILFKGARYYV LARGGLQVEP YYPRSLQDWG GIPEEVSGAL PRPDGSIIFF RDDRYWRLDQ AKLQATTSGR WATELPWMGC WHANSGSALF
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Can degrade casein. Could play a role in tissues homeostasis and repair.
基因功能參考文獻：
1. Circulating MMP-28 was elevated in atrial fibrillation PMID: 29729262
2. Results suggest a crucial role of MMP9 at the early stage of carcinogenesis in the large intestine. The increase in MMP9 and TIMP1 mRNA concentration and the decrease in MMP28 in the large intestinal tissue may be a confirmation of cancer. PMID: 28293015
3. These results proved for the first time that epilysin expression was significantly elevated in glioblastoma PMID: 25429835
4. A decreased level of IL-33 and an elevated concentration of MMP-28 were found in coronary heart disease patients and correlated with disease severity. PMID: 24710352
5. MMP28 mRNA expression is highest in healthy tissues when compared to diseased periodontal tissues. PMID: 24167355
6. Data established a seven-gene (AR, ESR2, GATA3, GBX2, KRT16, MMP28 and WNT11) prognostic signature to define a subset of triple-negative breast cancer (TNBC). PMID: 23549873
7. Over-expression of MMP28 provides protection against apoptosis induced by either serum-deprivation or treatment with a protein kinase inhibitor. PMID: 22040290
8. Gene expression of MMP28 in the intervertebral disk is not regulated by inflammatory mechanisms, is donor-dependent and cannot be positively or negatively linked to the grade of degeneration and only weakly to the occurrence of trauma. PMID: 21801383
9. basal expression of MMP-2, MMP-9, MMP-28, and Filaggrin was evaluated in oral keratinocytes to collect information about ability of cigarette smoke to modify basal expression pattern of these key enzymes in the absence of clinical signs in oral epithelium PMID: 21723775
10. MMP28 is frequently overexpressed during progression of gastric carcinoma, and contributes to tumor cell invasion and metastasis. PMID: 21615884
11. Findings presented here show the first documentation of intervertebral disc expression and production of MMP28 PMID: 20003223
12. MMP28 gene expression is regulated by Sp1 transcription factor acetylation. PMID: 20144149
13. Expression of MMP-21 and MMP-28 seems to associate with the Merkel cell carcinoma of lesser malignant potential. PMID: 19921252
14. Epilysin (MMP-28) expression is associated with cell proliferation during epithelial repair. PMID: 12164918
15. Results suggest inhibition of MMP-28 may be beneficial under conditions of dysmyelination. PMID: 18778487
16. Data demonstrate that expression of MMP28 alters keratinocyte phenotype towards a more adhesive, less migratory behaviour. PMID: 19375502
17. Epilysin (MMP-28) is deposited to the basolateral extracellular matrix of epithelial cells. PMID: 19379669
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亞細胞定位：

Secreted, extracellular space, extracellular matrix.
蛋白家族：

Peptidase M10A family
組織特異性：

Expressed at high levels in testes and lung. Low levels are detected in kidney, pancreas and skin. Also expressed in fetal lung, brain, skeletal muscle and kidney. Expressed selectively in keratinocytes. Widely expressed in several carcinomas as well. Is
數據庫鏈接：

HGNC: 14366

OMIM: 608417

KEGG: hsa:79148

STRING: 9606.ENSP00000250144

UniGene: Hs.380710