Human Matrix metalloproteinase-28(MMP28) ELISA kit
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中文名稱:人基質金屬蛋白酶-28(MMP28)酶聯免疫試劑盒
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貨號:CSB-EL014675HU
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規格:96T/48T
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價格:¥3600/¥2500
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其他:
產品詳情
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產品描述:人基質金屬蛋白酶-28(MMP28)酶聯免疫試劑盒(CSB-EL014675HU)為雙抗夾心法ELISA試劑盒,定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的MMP28含量。MMP28即基質金屬蛋白酶 28,在組織修復、免疫調節等方面有重要作用。其研究機制主要聚焦于它對細胞外基質的降解及調節,參與維持組織穩態。還探究其在腫瘤等疾病進程里的作用,有望為相關疾病診治提供新方向。試劑盒檢測范圍為0.625 ng/mL-40 ng/mL,本試劑盒可滿足基礎科研領域對MMP28蛋白水平的定量分析需求,例如探索其在組織修復模型、慢性炎癥機制或疾病相關信號通路中的動態變化,為分子生物學、細胞功能研究及疾病機制解析提供可靠工具。本品僅用于科研,不用于臨床診斷,產品具體參數及操作步驟詳見產品說明書。
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別名:Epilysin ELISA Kit; Matrix metalloproteinase 28 ELISA Kit; Matrix metalloproteinase-28 ELISA Kit; MM 28 ELISA Kit; MM28 ELISA Kit; MMP 25 ELISA Kit; MMP 28 ELISA Kit; MMP-28 ELISA Kit; MMP25 ELISA Kit; MMP28 ELISA Kit; MMP28_HUMAN ELISA Kit
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縮寫:MMP28
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Uniprot No.:
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種屬:Homo sapiens (Human)
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樣本類型:serum, plasma, tissue homogenates, cell lysates
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檢測范圍:0.625 ng/mL-40 ng/mL
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靈敏度:0.156 ng/mL
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反應時間:1-5h
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樣本體積:50-100ul
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檢測波長:450 nm
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研究領域:Cancer
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測定原理:quantitative
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測定方法:Sandwich
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數據處理:
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貨期:3-5 working days
相關產品
靶點詳情
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功能:Can degrade casein. Could play a role in tissues homeostasis and repair.
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基因功能參考文獻:
- Circulating MMP-28 was elevated in atrial fibrillation PMID: 29729262
- Results suggest a crucial role of MMP9 at the early stage of carcinogenesis in the large intestine. The increase in MMP9 and TIMP1 mRNA concentration and the decrease in MMP28 in the large intestinal tissue may be a confirmation of cancer. PMID: 28293015
- These results proved for the first time that epilysin expression was significantly elevated in glioblastoma PMID: 25429835
- A decreased level of IL-33 and an elevated concentration of MMP-28 were found in coronary heart disease patients and correlated with disease severity. PMID: 24710352
- MMP28 mRNA expression is highest in healthy tissues when compared to diseased periodontal tissues. PMID: 24167355
- Data established a seven-gene (AR, ESR2, GATA3, GBX2, KRT16, MMP28 and WNT11) prognostic signature to define a subset of triple-negative breast cancer (TNBC). PMID: 23549873
- Over-expression of MMP28 provides protection against apoptosis induced by either serum-deprivation or treatment with a protein kinase inhibitor. PMID: 22040290
- Gene expression of MMP28 in the intervertebral disk is not regulated by inflammatory mechanisms, is donor-dependent and cannot be positively or negatively linked to the grade of degeneration and only weakly to the occurrence of trauma. PMID: 21801383
- basal expression of MMP-2, MMP-9, MMP-28, and Filaggrin was evaluated in oral keratinocytes to collect information about ability of cigarette smoke to modify basal expression pattern of these key enzymes in the absence of clinical signs in oral epithelium PMID: 21723775
- MMP28 is frequently overexpressed during progression of gastric carcinoma, and contributes to tumor cell invasion and metastasis. PMID: 21615884
- Findings presented here show the first documentation of intervertebral disc expression and production of MMP28 PMID: 20003223
- MMP28 gene expression is regulated by Sp1 transcription factor acetylation. PMID: 20144149
- Expression of MMP-21 and MMP-28 seems to associate with the Merkel cell carcinoma of lesser malignant potential. PMID: 19921252
- Epilysin (MMP-28) expression is associated with cell proliferation during epithelial repair. PMID: 12164918
- Results suggest inhibition of MMP-28 may be beneficial under conditions of dysmyelination. PMID: 18778487
- Data demonstrate that expression of MMP28 alters keratinocyte phenotype towards a more adhesive, less migratory behaviour. PMID: 19375502
- Epilysin (MMP-28) is deposited to the basolateral extracellular matrix of epithelial cells. PMID: 19379669
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亞細胞定位:Secreted, extracellular space, extracellular matrix.
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蛋白家族:Peptidase M10A family
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組織特異性:Expressed at high levels in testes and lung. Low levels are detected in kidney, pancreas and skin. Also expressed in fetal lung, brain, skeletal muscle and kidney. Expressed selectively in keratinocytes. Widely expressed in several carcinomas as well. Is
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