Recombinant Human Leucine zipper transcription factor-like protein 1 (LZTFL1)

中文名稱：

人LZTFL1重組蛋白
貨號：

CSB-YP885687HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人LZTFL1重組蛋白
貨號：

CSB-EP885687HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人LZTFL1重組蛋白
貨號：

CSB-EP885687HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人LZTFL1重組蛋白
貨號：

CSB-BP885687HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人LZTFL1重組蛋白
貨號：

CSB-MP885687HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

LZTFL1
Uniprot No.：

Q9NQ48
別名：

5530402H04Rik; 6130400H19Rik; AI414725; AW048545; BBS17; DKFZp686H2076; FLJ36386; Leucine zipper transcription factor like 1; Leucine zipper transcription factor like protein 1; Leucine zipper transcription factor-like protein 1; LZTFL 1; Lztfl1; Lztfl1 leucine zipper transcription factor-like 1; LZTL1_HUMAN; MGC106871; MGC108960; Putative uncharacterized protein DKFZp686H2076
種屬：

Homo sapiens (Human)
蛋白長度：

full length protein
表達區域：

1-299
氨基酸序列

MAELGLNEHH QNEVINYMRF ARSKRGLRLK TVDSCFQDLK ESRLVEDTFT IDEVSEVLNG LQAVVHSEVE SELINTAYTN VLLLRQLFAQ AEKWYLKLQT DISELENREL LEQVAEFEKA EITSSNKKPI LDVTKPKLAP LNEGGTAELL NKEILRLQEE NEKLKSRLKT IEIQATNALD EKSKLEKALQ DLQLDQGNQK DFIKAQDLSN LENTVAALKS EFQKTLNDKT ENQKSLEENL ATAKHDLLRV QEQLHMAEKE LEKKFQQTAA YRNMKEILTK KNDQIKDLRK RLAQYEPED
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
基因功能參考文獻：
1. LZTFL1 inhibits lung tumorigenesis PMID: 26364604
2. these data indicate that LZTFL1 modulates T cell activation and IL-5 levels. PMID: 26700766
3. LZTFL1 binds beta-catenin in the cytoplasm of the cell and inhibited its nuclear translocation PMID: 25005785
4. This special subtype of polydactyly in BBS patients is easily identified on clinical examination and prompts for priority sequencing of LZTFL1 (BBS17). PMID: 23692385
5. The absence of LZTFL1 leads to a BBS phenotype with enhanced developmental abnormalities associated with cellular Shh dysfunction. LZTFL1 is a novel BBS gene (BBS17). PMID: 22510444
6. Our findings suggest that LZTFL1 is an important regulator of BBSome ciliary trafficking and hedgehog signaling PMID: 22072986
7. LZTFL1 may inhibit tumorigenesis by stabilizing E-cadherin-mediated adherens junction formation and promoting epithelial cell differentiation. PMID: 20233871
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相關疾病：

Bardet-Biedl syndrome 17 (BBS17)
亞細胞定位：

Cytoplasm.
蛋白家族：

LZTFL1 family
組織特異性：

Expressed in prostate, ovary, stomach, pancreas, esophagus, breast, liver, bladder, kidney, thyroid, colon and lung (at protein level). Down-regulated in multiple primary tumors (at protein level). Detected in testis, heart, skeletal muscle, thymus, splee
數據庫鏈接：

HGNC: 6741

OMIM: 606568

KEGG: hsa:54585

STRING: 9606.ENSP00000296135

UniGene: Hs.30824