LZTFL1 Antibody
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中文名稱：LZTFL1兔多克隆抗體
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貨號：CSB-PA217118
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA217118(LZTFL1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200) -
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: Human transitional cell carcinoma tissue, 293T cells, A172 cells, human testis tissue, Hela cells, Primary antibody: CSB-PA217118(LZTFL1 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
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其他：
產品詳情
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Uniprot No.：
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基因名：LZTFL1
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別名：5530402H04Rik antibody; 6130400H19Rik antibody; AI414725 antibody; AW048545 antibody; BBS17 antibody; DKFZp686H2076 antibody; FLJ36386 antibody; Leucine zipper transcription factor like 1 antibody; Leucine zipper transcription factor like protein 1 antibody; Leucine zipper transcription factor-like protein 1 antibody; LZTFL 1 antibody; Lztfl1 antibody; Lztfl1 leucine zipper transcription factor-like 1 antibody; LZTL1_HUMAN antibody; MGC106871 antibody; MGC108960 antibody; Putative uncharacterized protein DKFZp686H2076 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Fusion protein of Human LZTFL1
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 WB 1:500-1:2000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
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基因功能參考文獻：
- LZTFL1 inhibits lung tumorigenesis PMID: 26364604
- these data indicate that LZTFL1 modulates T cell activation and IL-5 levels. PMID: 26700766
- LZTFL1 binds beta-catenin in the cytoplasm of the cell and inhibited its nuclear translocation PMID: 25005785
- This special subtype of polydactyly in BBS patients is easily identified on clinical examination and prompts for priority sequencing of LZTFL1 (BBS17). PMID: 23692385
- The absence of LZTFL1 leads to a BBS phenotype with enhanced developmental abnormalities associated with cellular Shh dysfunction. LZTFL1 is a novel BBS gene (BBS17). PMID: 22510444
- Our findings suggest that LZTFL1 is an important regulator of BBSome ciliary trafficking and hedgehog signaling PMID: 22072986
- LZTFL1 may inhibit tumorigenesis by stabilizing E-cadherin-mediated adherens junction formation and promoting epithelial cell differentiation. PMID: 20233871
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相關疾?。?/div>Bardet-Biedl syndrome 17 (BBS17)亞細胞定位：Cytoplasm.蛋白家族：LZTFL1 family組織特異性：Expressed in prostate, ovary, stomach, pancreas, esophagus, breast, liver, bladder, kidney, thyroid, colon and lung (at protein level). Down-regulated in multiple primary tumors (at protein level). Detected in testis, heart, skeletal muscle, thymus, splee數據庫鏈接：
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