Recombinant Human Lethal (2) giant larvae protein homolog 2 (LLGL2), partial

中文名稱：

人LLGL2重組蛋白
貨號：

CSB-YP764711HU
說明書：

MSDS Datasheet
規格：
來源：

Yeast
其他：

中文名稱：

人LLGL2重組蛋白
貨號：

CSB-EP764711HU
說明書：

MSDS Datasheet
規格：
來源：

E.coli
其他：

中文名稱：

人LLGL2重組蛋白
貨號：

CSB-EP764711HU-B
說明書：

MSDS Datasheet
規格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人LLGL2重組蛋白
貨號：

CSB-BP764711HU
說明書：

MSDS Datasheet
規格：
來源：

Baculovirus
其他：

中文名稱：

人LLGL2重組蛋白
貨號：

CSB-MP764711HU
說明書：

MSDS Datasheet
規格：
來源：

Mammalian cell
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

>85% (SDS-PAGE)
基因名：

LLGL2
Uniprot No.：

Q6P1M3
別名：

HGL; Human giant larvae homolog; L2GL2; L2GL2_HUMAN; Lethal 2 giant larvae protein homolog 2; Lethal giant larvae homolog 2; Lethal(2) giant larvae protein homolog 2; LGL2; LLGL2
種屬：

Homo sapiens (Human)
蛋白長度：

Partial
蛋白標簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產品評價

靶點詳情

功能：

Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity.
基因功能參考文獻：
1. The crystal structures of the Dlg4 GK domain in complex with two phosphor-Lgl2 peptides reveal the molecular mechanism underlying the specific and phosphorylation-dependent Dlg/Lgl complex formation. PMID: 24513855
2. It is correlated with lymphatic invasion and lymph node metastasis. PMID: 24318287
3. Loss or aberrant Lgl2 staining was useful in identifying Barrett gastric foveolar dysplasia PMID: 23332925
4. Hugl-2 induces MET and suppresses Snail tumorigenesis. PMID: 22580609
5. Hugl1 and Hugl2 play an essential role in the maintenance of breast epithelial polarity and differentiated cell morphology, as well as growth control. PMID: 23110097
6. There is a role of Lgl2 immunohistochemistry as an adjunct in the diagnosis of foveolar-type gastric dysplasia. PMID: 20941506
7. Lgl2 differentiates pancreatic intraepithelial neoplasia-3 and ductal adenocarcinoma of the pancreas from lower-grade pancreatic intraepithelial neoplasias. PMID: 20233622
8. binding between Lgl2 and LGN play a role in mitotic spindle organization through regulating formation of the LGN.NuMA complex; Lgl2 forms a Lgl2.Par-6.aPKC.LGN complex, which responds to mitotic signaling to establish normal cell division PMID: 15632202
9. The identification and functional characterization of the promoter region ( approximately 1.2kb) of the Hugl-2 gene are reported. PMID: 18155665
10. Retention of Lgl2 expression is critical for the epithelial phenotype;its loss might be involved in metastasis. PMID: 18199550
11. We propose that Lgl2 may be a potential marker to rule out gastric epithelial dysplasia and adenocarcinoma in diagnostic specimens. PMID: 19407852
顯示更多

收起更多
亞細胞定位：

Cytoplasm. Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells.
蛋白家族：

WD repeat L(2)GL family
數據庫鏈接：

HGNC: 6629

KEGG: hsa:3993

STRING: 9606.ENSP00000376333

UniGene: Hs.514477