LLGL2 Antibody

中文名稱：

LLGL2兔多克隆抗體
貨號：

CSB-PA764711LA01HU
規格：

￥440
圖片：
Immunofluorescent analysis of MCF-7 cells using CSB-PA764711LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) LLGL2 Polyclonal antibody
Uniprot No.：

Q6P1M3
基因名：

LLGL2
別名：

HGL antibody; Human giant larvae homolog antibody; L2GL2 antibody; L2GL2_HUMAN antibody; Lethal 2 giant larvae protein homolog 2 antibody; Lethal giant larvae homolog 2 antibody; Lethal(2) giant larvae protein homolog 2 antibody; LGL2 antibody; LLGL2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Lethal(2) giant larvae protein homolog 2 protein (251-505AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，LLGL2 Antibody (CSB-PA764711LA01HU)，的標記方式是Non-conjugated。對于LLGL2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA764711LB01HU	LLGL2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA764711LC01HU	LLGL2 Antibody, FITC conjugated
Biotin	CSB-PA764711LD01HU	LLGL2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IF

推薦稀釋比：

Application	Recommended Dilution
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity.
基因功能參考文獻：
1. The crystal structures of the Dlg4 GK domain in complex with two phosphor-Lgl2 peptides reveal the molecular mechanism underlying the specific and phosphorylation-dependent Dlg/Lgl complex formation. PMID: 24513855
2. It is correlated with lymphatic invasion and lymph node metastasis. PMID: 24318287
3. Loss or aberrant Lgl2 staining was useful in identifying Barrett gastric foveolar dysplasia PMID: 23332925
4. Hugl-2 induces MET and suppresses Snail tumorigenesis. PMID: 22580609
5. Hugl1 and Hugl2 play an essential role in the maintenance of breast epithelial polarity and differentiated cell morphology, as well as growth control. PMID: 23110097
6. There is a role of Lgl2 immunohistochemistry as an adjunct in the diagnosis of foveolar-type gastric dysplasia. PMID: 20941506
7. Lgl2 differentiates pancreatic intraepithelial neoplasia-3 and ductal adenocarcinoma of the pancreas from lower-grade pancreatic intraepithelial neoplasias. PMID: 20233622
8. binding between Lgl2 and LGN play a role in mitotic spindle organization through regulating formation of the LGN.NuMA complex; Lgl2 forms a Lgl2.Par-6.aPKC.LGN complex, which responds to mitotic signaling to establish normal cell division PMID: 15632202
9. The identification and functional characterization of the promoter region ( approximately 1.2kb) of the Hugl-2 gene are reported. PMID: 18155665
10. Retention of Lgl2 expression is critical for the epithelial phenotype;its loss might be involved in metastasis. PMID: 18199550
11. We propose that Lgl2 may be a potential marker to rule out gastric epithelial dysplasia and adenocarcinoma in diagnostic specimens. PMID: 19407852
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亞細胞定位：

Cytoplasm. Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells.
蛋白家族：

WD repeat L(2)GL family
數據庫鏈接：

HGNC: 6629

KEGG: hsa:3993

STRING: 9606.ENSP00000376333

UniGene: Hs.514477

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