Recombinant Human LIM domain transcription factor LMO4 (LMO4)

中文名稱：

人LMO4重組蛋白
貨號：

CSB-EP013011HU
說明書：

MSDS Datasheet
規格：

￥1836
圖片：
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

純度：

Greater than 90% as determined by SDS-PAGE.
基因名：

LMO4
Uniprot No.：

P61968
別名：

Breast tumor autoantigen; LIM domain only 4; LIM domain only protein 4; LIM domain transcription factor LMO 4; LIM domain transcription factor LMO4; LMO 4; LMO-4; LMO4; LMO4_HUMAN; OTTHUMP00000011905; OTTHUMP00000011906
種屬：

Homo sapiens (Human)
蛋白長度：

Full Length
來源：

E.coli
分子量：

45.0kDa
表達區域：

1-165aa
氨基酸序列

MVNPGSSSQPPPVTAGSLSWKRCAGCGGKIADRFLLYAMDSYWHSRCLKCSCCQAQLGDIGTSCYTKSGMILCRNDYIRLFGNSGACSACGQSIPASELVMRAQGNVYHLKCFTCSTCRNRLVPGDRFHYINGSLFCEHDRPTALINGHLNSLQSNPLLPDQKVC
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
蛋白標簽：

N-terminal GST-tagged
產品提供形式：

Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
緩沖液：

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
儲存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA：

Please contact us to get it.

產品評價

靶點詳情

功能：

Probable transcriptional factor.
基因功能參考文獻：
1. Lmo4 participates in the regulation of lung epithelial cell proliferation but is not essential for tumor progression. PMID: 26048572
2. LMO4 appears to form a hub in protein-protein interaction networks, linking numerous pathways within cells. PMID: 25310299
3. Clim2, in a complex with LMO4, supports mammary stem cells by directly targeting the Fgfr2 promoter in basal cells to increase its expression PMID: 25079073
4. Existence of a region in the lateral portion of the mammalian cochlea that is competent to make an organ of Corti is demonstrated in the absence of LMO4 function. PMID: 25057208
5. Low LMO4 mRNA levels were associated with response to erlotinib in non-small-cell lung cancer. PMID: 23407556
6. oncoprotein HBXIP is able to activate the transcriptional coregulatory protein LMO4 through transcription factor Sp1 in promotion of proliferation of breast cancer cells. PMID: 23291272
7. Data suggest that overexpression of LMO4 may disrupt some of the normal tumour suppressor activities of CtIP, thereby contributing to breast cancer progression. PMID: 23353824
8. the association of high levels of LMO4 with aggressive neuroblastomas is dependent on LMO4 regulation of cadherin expression and hence, tumor invasiveness PMID: 23407937
9. LMO4 is a direct target of p53 and inhibits p53-mediated proliferative inhibition of breast cancer cells through interacting p53 PMID: 22906635
10. LMO4 is over-expressed in highly invasive rhabdomyosarcoma, alveolar cells PMID: 21271214
11. LMO4 expression in squamous cell carcinoma of the anterior tongue PMID: 21362019
12. data indicate that LMO4 has similar cellular effects in normal mammary epithelial cells and breast cancer cells, and also provide direct evidence for the idea that normal development and carcinogenesis share conserved molecular mechanisms PMID: 20526802
13. LMO4 protects neurons from ischemic brain injury, in part through its requirement as an essential cofactor of PPAR gamma PMID: 19020036
14. These findings reveal a novel complex between BRCA1, LMO4, and CtIP and indicate a role for LMO4 as a repressor of BRCA1 activity in breast tissue. PMID: 11751867
15. 1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex PMID: 12153047
16. Lmo4 RNA overexpression interferes with neuritic outgrowth,anti-sense Lmo4 RNA expression favors neuritogenesis in SH-SY5Y cells. Changes in Lmo4 RNA expression levels might alter the rate of neuritic outgrowth in the developing and adult nervous system. PMID: 12877980
17. LMO4 interaction modulates the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling PMID: 15677447
18. LMO4 is consistently more highly expressed in the embryonic right perisylvian cerebral cortex than in the left PMID: 15894532
19. LMO4 in breast epithelium contributes directly to breast neoplasia by altering the rate of cellular proliferation and promoting cell invasion. PMID: 15897450
20. Artificial intramolecular cyclic protein complex between two interacting proteins: the largely unstable LIM-only protein 4 (LMO4) and an unstructured domain of LIM domain binding protein 1 (ldb1). PMID: 17001033
21. In this study, patients whose tumours exhibited high LMO4 expression had a significant survival advantage following operative resection PMID: 18231110
22. Results suggested that LMO4 is overexpressed at late stages in carcinogenesis of pancreatic cancer. PMID: 19099607
23. Lmo4 expression coincides with the timing of the development of the somatosensory barrel field. PMID: 19111533
24. LMO4 is a novel cell cycle regulator with a key role in mediating ErbB2-induced proliferation, a hallmark of ErbB2-positive disease. PMID: 19648968
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數據庫鏈接：

HGNC: 6644

OMIM: 603129

KEGG: hsa:8543

STRING: 9606.ENSP00000359573

UniGene: Hs.436792