LEFTY2 Recombinant Monoclonal Antibody
-
中文名稱：LEFTY2重組抗體
-
貨號：CSB-RA171603A0HU
-
規格：￥1320
-
圖片：
-
Western Blot
Positive WB detected in: Ntera-2 whole cell lysate, Hela whole cell lysate
All lanes: LEFTY2 antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 41, 38 kDa
Observed band size: 36-45 kDa
-
-
其他：
產品詳情
-
產品描述：CSB-RA171603A0HU LEFTY2 Recombinant Monoclonal Antibody是針對發育調控關鍵因子LEFTY2設計的高特異性檢測工具。該抗體靶向的LEFTY2蛋白屬于TGF-β超家族成員，在胚胎左右軸模式形成、組織器官發育及細胞命運決定中發揮重要作用，同時參與腫瘤微環境調控等病理過程。經嚴格驗證，本重組單克隆抗體在Western Blot（WB）實驗中表現出優異的靶標識別能力，推薦使用稀釋比為1:500-1:2000時能清晰檢測目標蛋白表達，同時在ELISA平臺也具備可靠檢測性能，適用于多種哺乳動物細胞裂解液或組織樣本的分析。研究人員可利用該抗體探索胚胎發育異常機制、干細胞分化調控以及腫瘤發生發展過程中LEFTY2介導的信號通路，特別是在研究器官不對稱發育、癌癥細胞侵襲轉移抑制、以及TGF-β超家族配體互作網絡等領域具有重要應用價值。該產品采用重組表達技術保證批次穩定性，為發育生物學、腫瘤學及細胞信號轉導研究提供高質量的實驗保障。
-
Uniprot No.：
-
基因名：
-
別名：Left-right determination factor 2 (Endometrial bleeding-associated factor) (Left-right determination factor A) (Protein lefty-2) (Protein lefty-A) (Transforming growth factor beta-4) (TGF-beta-4), LEFTY2, EBAF LEFTA LEFTYA TGFB4
-
反應種屬：Human
-
免疫原：A synthesized peptide derived from human LEFTY2
-
免疫原種屬：Homo sapiens (Human)
-
標記方式：Non-conjugated
-
克隆類型：Monoclonal
-
抗體亞型：Rabbit IgG
-
純化方式：Affinity-chromatography
-
克隆號：10G2
-
濃度：It differs from different batches. Please contact us to confirm it.
-
保存緩沖液：Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
-
產品提供形式：Liquid
-
應用范圍：ELISA, WB
-
推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 -
Protocols：
-
儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
-
功能：Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
-
基因功能參考文獻：
- functional role of LEFTY during progesterone therapy for endometrial carcinoma PMID: 29268772
- LeftyA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization, cell softening and cell shrinkage. PMID: 27404958
- LEFTY2 down-regulates MKi67 expression and FAK activity, up-regulates miR-200a and E-cadherin, and is thus a powerful negative regulator of endometrial cell proliferation and migration. PMID: 27497669
- LEFTY2 regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1. PMID: 27606670
- Lefty A may account for the tumor suppressive activity of human adult stem cells. PMID: 22469982
- Findings suggest that Lefty2 is negatively modulated by miR-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification. PMID: 21266536
- Findings show that during embryonic development, EBAF/LEFTY B plays important roles in decidualization and embryo implantation. PMID: 21401636
- findings show that the TGFB4 (ebaf) mRNA has distinct tumor specific expression PMID: 9230066
- may provide a crucial signal for endometrial breakdown and bleeding by triggering expression of several matrix metalloproteinases PMID: 12215426
- nodal and the inhibitors of Nodal signaling, lefty-A and lefty-B, are down-regulated very early upon differentiation of human embryonic stem cells PMID: 15308665
- Addition of recombinant LEFTY-A to explants induced MMP-9 in most samples, a response prevented by ovarian steroids. PMID: 15536155
- LEFTY proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation. PMID: 17038673
顯示更多
收起更多
-
相關疾?。?/div>Left-right axis malformations (LRAM)亞細胞定位：Secreted.蛋白家族：TGF-beta family組織特異性：Mesenchymal cells of the endometrial stroma.數據庫鏈接：
Most popular with customers
-
-
YWHAB Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC, IF, FC
Species Reactivity: Human, Mouse, Rat
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-
