LEFTY2 Antibody

說明書

中文名稱：

LEFTY2兔多克隆抗體
貨號：

CSB-PA991744
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA991744(LEFTY2 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA991744(LEFTY2 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 8%SDS-PAGE,Lysate: 40 μg,,Primary antibody: CSB-PA991744(LEFTY2 Antibody) at dilution 1/800 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 30 seconds
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

O00292
基因名：

LEFTY2
別名：

EBAF antibody; Endometrial bleeding associated factor (left right determination factor A transforming growth factor beta superfamily) antibody; Endometrial bleeding associated factor antibody; Endometrial bleeding-associated factor antibody; Left right determination factor 2 antibody; Left right determination factor A antibody; Left-right determination factor 2 antibody; Left-right determination factor A antibody; LEFTA antibody; LEFTY 2 antibody; LEFTY2 antibody; LEFTYA antibody; LFTY2 transforming growth factor; beta -4 antibody; LFTY2; mouse; homolog of antibody; LFTY2_HUMAN antibody; MGC46222 antibody; Protein lefty 2 antibody; Protein lefty A antibody; Protein lefty-2 antibody; Protein lefty-A antibody; Protein lefty2 antibody; PSEC0024 antibody; TGF beta 4 antibody; TGF-beta-4 antibody; TGFB4 antibody; Transforming growth factor beta 4 antibody; Transforming growth factor beta-4 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Full length fusion protein
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.
基因功能參考文獻：
1. functional role of LEFTY during progesterone therapy for endometrial carcinoma PMID: 29268772
2. LeftyA leads to disruption of Rac1 and Pak1 activity with subsequent actin depolymerization, cell softening and cell shrinkage. PMID: 27404958
3. LEFTY2 down-regulates MKi67 expression and FAK activity, up-regulates miR-200a and E-cadherin, and is thus a powerful negative regulator of endometrial cell proliferation and migration. PMID: 27497669
4. LEFTY2 regulates the expression and activity of ENaC in endometrial epithelial cells via SGK1. PMID: 27606670
5. Lefty A may account for the tumor suppressive activity of human adult stem cells. PMID: 22469982
6. Findings suggest that Lefty2 is negatively modulated by miR-302s in hESCs, which plays an important role in maintaining the balance between pluripotency and germ layer specification. PMID: 21266536
7. Findings show that during embryonic development, EBAF/LEFTY B plays important roles in decidualization and embryo implantation. PMID: 21401636
8. findings show that the TGFB4 (ebaf) mRNA has distinct tumor specific expression PMID: 9230066
9. may provide a crucial signal for endometrial breakdown and bleeding by triggering expression of several matrix metalloproteinases PMID: 12215426
10. nodal and the inhibitors of Nodal signaling, lefty-A and lefty-B, are down-regulated very early upon differentiation of human embryonic stem cells PMID: 15308665
11. Addition of recombinant LEFTY-A to explants induced MMP-9 in most samples, a response prevented by ovarian steroids. PMID: 15536155
12. LEFTY proteins, which are known to play a major role during mouse gastrulation, are transiently expressed during human embryonic stem cell differentiation. PMID: 17038673
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相關疾病：

Left-right axis malformations (LRAM)
亞細胞定位：

Secreted.
蛋白家族：

TGF-beta family
組織特異性：

Mesenchymal cells of the endometrial stroma.
數據庫鏈接：

HGNC: 3122

OMIM: 601877

KEGG: hsa:7044

STRING: 9606.ENSP00000355785

UniGene: Hs.520187

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