Gipr Recombinant Monoclonal Antibody

說明書

中文名稱：

Gipr重組抗體
貨號：

CSB-RA009438MA1MO
規(guī)格：

￥1320
圖片：
The Binding Activity of Mouse Gipr with Anti-Mouse Gipr recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse Gipr (CSB-MP009438MO1) at 2 μg/mL can bind Anti-Mouse Gipr recombinant antibody , the EC₅₀ is 8.622-11.36 ng/mL.

The Binding Activity of Rat Giprwith Anti-Mouse Gipr recombinant antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Rat Gipr (CSB-MP009438RA1) at 2 μg/mL can bind Anti-Mouse Gipr recombinant antibody, the EC₅₀ is 6.946-8.740 ng/mL.
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

產(chǎn)品描述：

CSB-RA009438MA1MO Gipr重組單克隆抗體是針對胃抑制多肽受體（GIPR）研發(fā)的高特異性檢測工具。GIPR是B類G蛋白偶聯(lián)受體家族成員，在調(diào)控胰島素分泌、脂質(zhì)代謝及能量平衡中發(fā)揮重要作用。本抗體通過重組蛋白免疫技術(shù)制備，經(jīng)ELISA平臺嚴格驗證，可精準識別天然及重組表達的GIPR蛋白，展現(xiàn)出優(yōu)異的結(jié)合活性和批次穩(wěn)定性。其高靈敏度與低交叉反應性特征，使其適用于體外分析中GIPR的定量檢測及功能研究，例如探究GIPR在2型糖尿病、肥胖癥等代謝性疾病中的分子機制，或用于評估藥物干預對受體活性的調(diào)控效應。該產(chǎn)品適用于細胞培養(yǎng)上清、組織裂解液等樣本類型的檢測，為研究胃腸道-胰島軸信號傳導、能量代謝調(diào)控網(wǎng)絡提供了可靠的實驗支持，滿足基礎(chǔ)科研中對GIPR靶點的高精度分析需求。
Uniprot No.：

Q0P543
基因名：

Gipr
別名：

Gastric inhibitory polypeptide receptor; GIP-R; Glucose-dependent insulinotropic polypeptide receptor; Gipr
反應種屬：

Mouse, Rat
免疫原：

Recombinant Mouse Gipr protein
免疫原種屬：

Mus musculus (Mouse)
標記方式：

Non-conjugated
克隆類型：

Monoclonal
抗體亞型：

mIgG2a
純化方式：

Affinity-chromatography
克隆號：

12C6
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
基因功能參考文獻：
1. The study provides evidence that the insulinotropic action of zfGIP in mammalian systems involves activation of both the GLP-1 and the GIP receptors but not the glucagon receptor PMID: 29157578
2. Microarray analysis revealed that pregnancy-specific glycoprotein 17 (Psg17), a potential CD9-binding partner, was significantly decreased in GIP receptor-knockout (Gipr-/-) testes. PMID: 28430907
3. GIPR signaling in adipose tissue plays a critical role in high fat diet-induced insulin resistance and hepatic steatosis in vivo, which may involve IL-6 signaling. PMID: 28096257
4. Genetic deletion of both GLP-1 and GIP receptors reveals that they are required to maintain an adequate islet number in adulthood and to maintain normal beta cell responses to glucose. PMID: 27020250
5. Results suggest the beneficial effects of glucose-dependent insulinotropic polypeptide on periodontal disease. PMID: 27181102
6. Gipr(-/-) offspring of mice exposed to high fat diet(HFD) during pregnancy/lactation became insulin resistant and obese and exhibited increased adipose tissue inflammation and decreased peripheral tissue substrate utilization after reintroduction of HFD. PMID: 26631738
7. Beta-cell Gipr KO mice exhibit lower levels of meal-stimulated insulin secretion, decreased expansion of adipose tissue mass and preservation of insulin sensitivity and decreased TCF1 expression. PMID: 26642437
8. Gipr is expressed in healthy arteries, predominantly in endothelial cells. PMID: 26395740
9. These data highlighted the importance of intact GIPR signalling and dietary composition in modulating memory and learning, and hippocampal pathways involved in the maintenance of synaptic plasticity PMID: 25760229
10. Functional GIP receptors play a major role in islet compensatory response to high fat feeding in mice. PMID: 25688757
11. our data demonstrate that the expression of GLP-1R and GIPR is regulated by glucose concentrations in MC3T3-E1 cells undergoing differentiation induced by BMP-2. PMID: 24866833
12. Results show that GIPR undergoes trafficking between the plasma membrane and intracellular compartments of both GIP-stimulated and unstimulated adipocytes. PMID: 25047836
13. Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor. PMID: 23689510
14. a role of the adipocyte GIPr in nutrient-dependent regulation of body weight and lean mass, but it does not support a direct and independent role for the adipocyte or beta-cell GIPr in promoting adipogenesis. PMID: 22027838
15. Gipr is essential for adrenal steroidogenesis and links high fat (HF) feeding to increased levels of corticosterone, reduced glucocorticoid levels do not significantly contribute to the enhanced metabolic phenotypes in HF-fed Gipr(-/-) mice. PMID: 22043004
16. GIPR(dn) transgenic mice show a disturbed expansion of the endocrine pancreas, due to perturbed islet neogenesis. PMID: 21818396
17. GIP receptors play an important role in cognition, neurotransmission, and cell proliferation. PMID: 21273318
18. Both GIPR protein and mRNA expression increased during cell differentiation, and this increase was associated with upregulation of nuclear levels of SREBP-1c and PPARgamma, as well as acetylation of histones H3/H4. PMID: 21245029
19. GIPR(-/-) mice exhibit altered islet structure and topography and increased islet sensitivity to glucagon-like peptide-1 despite a decrease in pancreatic insulin content and gene expression PMID: 12540373
20. Results demonstrate that glucose intolerance was additively increased during oral glucose absorption when both gastric inhibitory polypeptide receptors and glucagon-like peptide 1 receptors were inactivated. PMID: 14966573
21. intact signaling of G-protein coupled receptors is involved in postnatal islet and beta-cell development and neogenesis of the pancreatic islets PMID: 15582721
22. Adult GIP receptor knock-out mice exhibit a significantly lower number of newborn cells in the hippocampal dentate gyrus compared with wild-type mice. PMID: 15716418
23. long term activation of the GIP receptor by daily treatment with N-AcGIP(LysPAL37) improved glucose tolerance due to enhancement of pancreatic beta cell glucose responsiveness and insulin secretion. PMID: 16181707
24. Both incretins secretion depends on mechanisms involving their own receptors and GLP-1 further requires GLUT2. PMID: 17681422
25. relative reduction of truncated GIPR expression may be involved in hypersensitivity of GIPR and hyperinsulinemia in diet-induced obese mice PMID: 17971513
26. Double incretin receptor knockout mice exhibit enhanced insulin action compared with wild-type mice when fed a regular diet and are protected from high-fat diet-induced obesity and insulin resistance. PMID: 17977951
27. Gastric inhibitory peptide receptor interacts with estrogens in the hypothalamic regulation of food intake in mice. PMID: 18505834
28. Results suggest that activation of the gastric inhibitory polypeptide receptor can improve diabetes control in high-fat-fed mice. PMID: 19073224
29. Analyses with GIPR-deficient mice suggest a role of GIP/GIPR signal transduction in promoting spontaneous recovery after nerve crush; injury of GIPR-deficient mouse sciatic nerve revealed impaired axonal regeneration. PMID: 19170165
30. Report differential importance of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide 1 receptor signaling for beta cell survival in mice. PMID: 19766644
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 2 family
數(shù)據(jù)庫鏈接：

KEGG: mmu:381853

STRING: 10090.ENSMUSP00000092384

UniGene: Mm.333633

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