ZFYVE9 Antibody, FITC conjugated

說明書

中文名稱：

ZFYVE9兔多克隆抗體, FITC偶聯
貨號：

CSB-PA026477LC01HU
規格：

￥880
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ZFYVE9 Polyclonal antibody
Uniprot No.：

O95405
基因名：

ZFYVE9
別名：

CG15667 antibody; hSARA antibody; LD33044p antibody; Madh-interacting protein antibody; MADHIP antibody; Mothers against decapentaplegic homolog-interacting protein antibody; Novel serine protease antibody; NSP antibody; Receptor activation anchor antibody; SAR1 antibody; SARA antibody; SARA1 antibody; Smad anchor for receptor activation antibody; SMADIP antibody; ZFYV9_HUMAN antibody; ZFYVE9 antibody; Zinc finger FYVE domain-containing protein 9 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Zinc finger FYVE domain-containing protein 9 protein (683-926AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.
基因功能參考文獻：
1. we have identified endofin as an important signalling component required for basal and BMP-induced hepcidin expression. PMID: 26358513
2. SARA may serve as a potential novel target in pre-Epithelial-mesenchymal transition states for the amelioration renal fibrosis seen in chronic kidney diseases PMID: 26159183
3. PI3K-C2a was also required for TGFb receptor-mediated formation of SARA-Smad2/3 complex PMID: 25614622
4. The negative influence that perturbation of RNF11 and SARA levels exerts on the lysosomal degradation of EGFRs could underscore the significance of overexpression of RNF11 in certain cancers. PMID: 23222715
5. TGF-beta1 can induce epithelial-to-mesenchymal transition through reduction in SARA expression, SARA is also basally regulated by its interaction with PI3K. PMID: 22942286
6. no correlation between SARA expression and the levels of TGF-beta1-induced phosphorylation of Smads in various B-cell lymphomas PMID: 22819827
7. SARA binds to ERBIN using a new domain, which we have called the ERBID (ERBIN-binding domain) PMID: 21878490
8. After stimulation with glucose, expression of SARA decreased in a time-dependent manner in epithelium to mesenchymal transition of proximal tubule cells. PMID: 21200089
9. Expression of a SARA mutant protein lacking the FYVE finger inhibits downstream activin A signaling in endothelial cells. PMID: 11877415
10. role in rab5 mediated endocytosis PMID: 12432064
11. SARA MH2 domains function in TGF-beta signaling PMID: 15231848
12. internalization is important for transforming growth factor beta1-induced Smad2 association with Smad anchor for receptor activation (SARA) and Smad2-dependent signaling in human mesangial cells PMID: 15613484
13. SARA acts as a Smad anchor for receptor activation in BMP signaling. PMID: 17356069
14. Protein-protein and protein-lipid interactions organized by SARA regulate the vesicular targeting of rhodopsin-bearing axonemal vesicles to nascent discs at the base of the rod outer segment. PMID: 17693260
15. SARA has a role in regulating cell phenotype and its effects are mediated through modification of the balance between Smad2 and Smad3 signaling PMID: 19620243
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亞細胞定位：

Cytoplasm. Early endosome membrane.
組織特異性：

Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes.
數據庫鏈接：

HGNC: 6775

OMIM: 603755

KEGG: hsa:9372

STRING: 9606.ENSP00000287727

UniGene: Hs.532345

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