ZFYVE9 Antibody, Biotin conjugated
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中文名稱：ZFYVE9兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA026477LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) ZFYVE9 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：CG15667 antibody; hSARA antibody; LD33044p antibody; Madh-interacting protein antibody; MADHIP antibody; Mothers against decapentaplegic homolog-interacting protein antibody; Novel serine protease antibody; NSP antibody; Receptor activation anchor antibody; SAR1 antibody; SARA antibody; SARA1 antibody; Smad anchor for receptor activation antibody; SMADIP antibody; ZFYV9_HUMAN antibody; ZFYVE9 antibody; Zinc finger FYVE domain-containing protein 9 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Zinc finger FYVE domain-containing protein 9 protein (683-926AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.
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基因功能參考文獻：
- we have identified endofin as an important signalling component required for basal and BMP-induced hepcidin expression. PMID: 26358513
- SARA may serve as a potential novel target in pre-Epithelial-mesenchymal transition states for the amelioration renal fibrosis seen in chronic kidney diseases PMID: 26159183
- PI3K-C2a was also required for TGFb receptor-mediated formation of SARA-Smad2/3 complex PMID: 25614622
- The negative influence that perturbation of RNF11 and SARA levels exerts on the lysosomal degradation of EGFRs could underscore the significance of overexpression of RNF11 in certain cancers. PMID: 23222715
- TGF-beta1 can induce epithelial-to-mesenchymal transition through reduction in SARA expression, SARA is also basally regulated by its interaction with PI3K. PMID: 22942286
- no correlation between SARA expression and the levels of TGF-beta1-induced phosphorylation of Smads in various B-cell lymphomas PMID: 22819827
- SARA binds to ERBIN using a new domain, which we have called the ERBID (ERBIN-binding domain) PMID: 21878490
- After stimulation with glucose, expression of SARA decreased in a time-dependent manner in epithelium to mesenchymal transition of proximal tubule cells. PMID: 21200089
- Expression of a SARA mutant protein lacking the FYVE finger inhibits downstream activin A signaling in endothelial cells. PMID: 11877415
- role in rab5 mediated endocytosis PMID: 12432064
- SARA MH2 domains function in TGF-beta signaling PMID: 15231848
- internalization is important for transforming growth factor beta1-induced Smad2 association with Smad anchor for receptor activation (SARA) and Smad2-dependent signaling in human mesangial cells PMID: 15613484
- SARA acts as a Smad anchor for receptor activation in BMP signaling. PMID: 17356069
- Protein-protein and protein-lipid interactions organized by SARA regulate the vesicular targeting of rhodopsin-bearing axonemal vesicles to nascent discs at the base of the rod outer segment. PMID: 17693260
- SARA has a role in regulating cell phenotype and its effects are mediated through modification of the balance between Smad2 and Smad3 signaling PMID: 19620243
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亞細胞定位：Cytoplasm. Early endosome membrane.
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組織特異性：Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes.
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數據庫鏈接：
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