USO1 Antibody
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中文名稱：USO1兔多克隆抗體
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貨號：CSB-PA025694GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：USO1
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別名：General vesicular transport factor antibody; General vesicular transport factor p115 antibody; P115 antibody; Protein USO1 homolog antibody; TAP antibody; Transcytosis associated protein antibody; Transcytosis-associated protein antibody; Uso1 antibody; USO1_HUMAN antibody; VDP antibody; Vesicle docking protein antibody; Vesicle docking protein p115 antibody; Vesicle-docking protein antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human USO1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC,IF
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.
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基因功能參考文獻：
- USO1 gene may be a promising target for the therapy of human multiple myeloma and its diagnosis marker. PMID: 26898451
- USO1 gene has a critical role in human colon cancer: USO1 is involved in cell proliferation and cell migration of colon cancer cells. PMID: 26184508
- P115 promotes proliferation of gastric cancer cells through an interaction with MIF. PMID: 24379579
- Scyl1 interacts with 58K/formiminotransferase cyclodeaminase (FTCD) and golgin p115, and is required for the maintenance of Golgi morphology. PMID: 20209057
- p115 plays a critical role in mitosis progression, implicating it as the only known golgin to regulate both mitosis and apoptosis PMID: 21536679
- a conserved tethering function of the Golgi protein p115 CTF which promotes p53-ERK interaction for the amplification of the apoptotic signal. PMID: 21147777
- Data show that the number of tandem ARM repeats in an ARM fold ranges from 6 to 12. PMID: 20126549
- Data show that p115 degradation plays a key role in amplifying the apoptotic response independently of Golgi fragmentation. PMID: 12438416
- p115 acts directly, rather than via a tether, to catalyze trans-SNARE complex formation preceding membrane fusion. PMID: 14736916
- The results suggest that p115 is involved in vesicular transport between endoplasmic reticulum and the Golgi, along with microtubule networks. PMID: 16256943
- The interaction between p115 and Cog2 was found to be essential for Golgi ribbon reformation after the disruption of the ribbon by p115 KD or brefeldin A treatment and recovery by re-expression of p115 or drug wash out, respectively. PMID: 17274799
- Golgi organization depends on mutually interacting domains in betaCOP and p115, suggesting that vesicle tethering at the Golgi involves p115 binding to the COPI coat PMID: 18434597
- nuclear import of the p115 CTF is required for it to stimulate the apoptotic response and suggest that its mode of action is confined to the nucleus. PMID: 19028683
- terminal repeat folds into the armadillo superhelical groove and allows homodimeric association with important implications for p115 mediated multiple protein interactions and tethering PMID: 19247479
- p115 is a critical intermediary component in the regulated secretion of MIF from monocytes/macrophages PMID: 19454686
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亞細胞定位：Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein.
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蛋白家族：VDP/USO1/EDE1 family
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數據庫鏈接：
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