USO1 Antibody

中文名稱：

USO1兔多克隆抗體
貨號：

CSB-PA025694LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA025694LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA025694LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) USO1 Polyclonal antibody
Uniprot No.：

O60763
基因名：

USO1
別名：

General vesicular transport factor antibody; General vesicular transport factor p115 antibody; P115 antibody; Protein USO1 homolog antibody; TAP antibody; Transcytosis associated protein antibody; Transcytosis-associated protein antibody; Uso1 antibody; USO1_HUMAN antibody; VDP antibody; Vesicle docking protein antibody; Vesicle docking protein p115 antibody; Vesicle-docking protein antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human General vesicular transport factor p115 protein (591-733AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，USO1 Antibody (CSB-PA025694LA01HU)，的標記方式是Non-conjugated。對于USO1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA025694LB01HU	USO1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA025694LC01HU	USO1 Antibody, FITC conjugated
Biotin	CSB-PA025694LD01HU	USO1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.
基因功能參考文獻：
1. USO1 gene may be a promising target for the therapy of human multiple myeloma and its diagnosis marker. PMID: 26898451
2. USO1 gene has a critical role in human colon cancer: USO1 is involved in cell proliferation and cell migration of colon cancer cells. PMID: 26184508
3. P115 promotes proliferation of gastric cancer cells through an interaction with MIF. PMID: 24379579
4. Scyl1 interacts with 58K/formiminotransferase cyclodeaminase (FTCD) and golgin p115, and is required for the maintenance of Golgi morphology. PMID: 20209057
5. p115 plays a critical role in mitosis progression, implicating it as the only known golgin to regulate both mitosis and apoptosis PMID: 21536679
6. a conserved tethering function of the Golgi protein p115 CTF which promotes p53-ERK interaction for the amplification of the apoptotic signal. PMID: 21147777
7. Data show that the number of tandem ARM repeats in an ARM fold ranges from 6 to 12. PMID: 20126549
8. Data show that p115 degradation plays a key role in amplifying the apoptotic response independently of Golgi fragmentation. PMID: 12438416
9. p115 acts directly, rather than via a tether, to catalyze trans-SNARE complex formation preceding membrane fusion. PMID: 14736916
10. The results suggest that p115 is involved in vesicular transport between endoplasmic reticulum and the Golgi, along with microtubule networks. PMID: 16256943
11. The interaction between p115 and Cog2 was found to be essential for Golgi ribbon reformation after the disruption of the ribbon by p115 KD or brefeldin A treatment and recovery by re-expression of p115 or drug wash out, respectively. PMID: 17274799
12. Golgi organization depends on mutually interacting domains in betaCOP and p115, suggesting that vesicle tethering at the Golgi involves p115 binding to the COPI coat PMID: 18434597
13. nuclear import of the p115 CTF is required for it to stimulate the apoptotic response and suggest that its mode of action is confined to the nucleus. PMID: 19028683
14. terminal repeat folds into the armadillo superhelical groove and allows homodimeric association with important implications for p115 mediated multiple protein interactions and tethering PMID: 19247479
15. p115 is a critical intermediary component in the regulated secretion of MIF from monocytes/macrophages PMID: 19454686
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亞細胞定位：

Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein.
蛋白家族：

VDP/USO1/EDE1 family
數據庫鏈接：

HGNC: 30904

OMIM: 603344

KEGG: hsa:8615

UniGene: Hs.744877

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