UBE2W Antibody
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中文名稱：UBE2W兔多克隆抗體
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貨號：CSB-PA025485GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：FLJ11011 antibody; hUBC 16 antibody; hUBC16 antibody; Probable ubiquitin conjugating enzyme E2 W antibody; Probable ubiquitin-conjugating enzyme E2 W antibody; UBC 16 antibody; UBC-16 antibody; UBC16 antibody; UBE 2W antibody; ube2w antibody; UBE2W_HUMAN antibody; Ubiquitin carrier protein W antibody; Ubiquitin conjugating enzyme 16 antibody; Ubiquitin conjugating enzyme E2 W antibody; Ubiquitin conjugating enzyme E2W antibody; Ubiquitin protein ligase W antibody; Ubiquitin-protein ligase W antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human UBE2W
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. UBE2W-catalyzed ubiquitination occurs also in the presence of inactive RING/U-box type E3s, i.e. lacking the active site cysteine residues to form thioester bonds with ubiquitin, or even in the absence of E3, albeit at a slower rate.
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基因功能參考文獻：
- Thus, although Rnf4 and Ube2w functionally interact in vitro, these genetic experiments indicate that in response to DNA damage Ube2w and Rnf4 function in distinct pathways. PMID: 27185577
- TRIM5alpha requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription. PMID: 26101372
- We show the ubequitin-conjugating enzyme (E2) Ube2w uses a unique mechanism to facilitate the specific ubiquitination of the alpha-amino group PMID: 25436519
- Ube2w has novel enzymatic properties that direct ubiquitination of the N terminus of substrates PMID: 23696636
- UBE2W regulates FANCD2 monoubiquitination by mechanisms different from UBE2T and HRR6. PMID: 21229326
- human Ubiquitin-conjugating enzyme (E2) is homologous to the Arabidopsis thaliana UBC-16 gene product and contains 2 nuclear localization signals PMID: 16368532
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亞細胞定位：Nucleus.
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蛋白家族：Ubiquitin-conjugating enzyme family
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組織特異性：Widely expressed, with highest expression in brain, liver, pancreas and heart.
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數據庫鏈接：
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