UBE2W Antibody

說(shuō)明書

中文名稱：

UBE2W兔多克隆抗體
貨號(hào)：

CSB-PA842638LA01HU
規(guī)格：

￥440
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) UBE2W Polyclonal antibody
Uniprot No.：

Q96B02
基因名：

UBE2W
別名：

FLJ11011 antibody; hUBC 16 antibody; hUBC16 antibody; Probable ubiquitin conjugating enzyme E2 W antibody; Probable ubiquitin-conjugating enzyme E2 W antibody; UBC 16 antibody; UBC-16 antibody; UBC16 antibody; UBE 2W antibody; ube2w antibody; UBE2W_HUMAN antibody; Ubiquitin carrier protein W antibody; Ubiquitin conjugating enzyme 16 antibody; Ubiquitin conjugating enzyme E2 W antibody; Ubiquitin conjugating enzyme E2W antibody; Ubiquitin protein ligase W antibody; Ubiquitin-protein ligase W antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Ubiquitin-conjugating enzyme E2 W protein (1-151AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，UBE2W Antibody (CSB-PA842638LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于UBE2W Antibody，我們還提供其他標(biāo)記。見下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA842638LB01HU	UBE2W Antibody, HRP conjugated	ELISA
FITC	CSB-PA842638LC01HU	UBE2W Antibody, FITC conjugated
Biotin	CSB-PA842638LD01HU	UBE2W Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. UBE2W-catalyzed ubiquitination occurs also in the presence of inactive RING/U-box type E3s, i.e. lacking the active site cysteine residues to form thioester bonds with ubiquitin, or even in the absence of E3, albeit at a slower rate.
基因功能參考文獻(xiàn)：
1. Thus, although Rnf4 and Ube2w functionally interact in vitro, these genetic experiments indicate that in response to DNA damage Ube2w and Rnf4 function in distinct pathways. PMID: 27185577
2. TRIM5alpha requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription. PMID: 26101372
3. We show the ubequitin-conjugating enzyme (E2) Ube2w uses a unique mechanism to facilitate the specific ubiquitination of the alpha-amino group PMID: 25436519
4. Ube2w has novel enzymatic properties that direct ubiquitination of the N terminus of substrates PMID: 23696636
5. UBE2W regulates FANCD2 monoubiquitination by mechanisms different from UBE2T and HRR6. PMID: 21229326
6. human Ubiquitin-conjugating enzyme (E2) is homologous to the Arabidopsis thaliana UBC-16 gene product and contains 2 nuclear localization signals PMID: 16368532
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亞細(xì)胞定位：

Nucleus.
蛋白家族：

Ubiquitin-conjugating enzyme family
組織特異性：

Widely expressed, with highest expression in brain, liver, pancreas and heart.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 25616

OMIM: 614277

KEGG: hsa:55284

STRING: 9606.ENSP00000454445

UniGene: Hs.128841

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