UBE2A Antibody
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中文名稱：UBE2A兔多克隆抗體
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貨號：CSB-PA025438GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：BHR6A antibody; hHR6A antibody; HR6A antibody; mHR6A antibody; MRXS30 antibody; MRXSN antibody; RAD6 homolog A antibody; RAD6A antibody; UBC2 antibody; UBCD6 antibody; UBE2A antibody; Ube2a ubiquitin-conjugating enzyme E2A antibody; UBE2A_HUMAN antibody; Ubiquitin carrier protein A antibody; Ubiquitin carrier protein antibody; Ubiquitin conjugating enzyme E2 17 kDa antibody; Ubiquitin conjugating enzyme E2 21.5 kDa antibody; Ubiquitin conjugating enzyme E2A (RAD6 homolog) antibody; Ubiquitin conjugating enzyme E2A antibody; Ubiquitin protein ligase A antibody; Ubiquitin-conjugating enzyme E2 A antibody; Ubiquitin-protein ligase A antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human UBE2A
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC,IF
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.
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基因功能參考文獻：
- RAD6 is upregulated in response to chemotherapy and significantly correlated with expression of ovarian cancer (OC) stem cell signaling genes ALDH1A1 and SOX2 and poor prognosis of OC patients. PMID: 28806395
- RAD6 promotes proteasome activity and nuclear translocation by enhancing the degradation of PSMF1 and the lamin B receptor. PMID: 28031328
- Data show that the ubiquitin-conjugating enzyme E2 RAD6A/B-MDM2 ubiquitin ligase machinery regulates anti-silencing function 1A protein (ASF1A) degradation. PMID: 26336826
- Results showed KCMF1 C-terminus binds directly to RAD6, whereas N-terminal domains interact with UBR4 and point mutations found in X-linked intellectual disability (XLID) patients specifically lose the interaction with KCMF1 and UBR4. PMID: 25582440
- This study investigates clinical and molecular data of two unrelated, affected males with chromosome Xq24 deletions encompassing UBE2A. PMID: 25287747
- RAD6 physically interacts with heterochromatin protein 1alpha and ubiquitinates HP1alpha at residue K154, thereby promoting heterochromatin protein 1alpha degradation through the autophagy pathway PMID: 25384975
- HHR6 and hRad18 can monoubiquitinate FANCD2 at lysine 561 in vitro. This activity may represent a novel stress response pathway. PMID: 24036990
- RNF168, in complex with RAD6A or RAD6B, is activated in the DNA-damage-induced protein ubiquitination cascade. PMID: 23525009
- RAD6A is a regulator of Parkin-dependent mitophagy plays a critical role in maintaining neuronal function. PMID: 23685073
- UBE2A specifically interacts with CDK9, but not CDK2 and is phosphorylated by CDK9 in vitro. PMID: 22592529
- RAD6 can form a ternary complex with MDM2 and p53 that contributes to the degradation of p53. PMID: 22083959
- UBE2A deficiency syndrome is reported in two male patients. PMID: 21108393
- showed that the function of FA signaling pathway is at least partly mediated through coupling with hRad6/hRad18 signaling (HHR6 pathway) PMID: 20967207
- Novel missense mutations in the ubiquitination-related gene UBE2A cause a recognizable X-linked mental retardation syndrome PMID: 20412111
- high resolution backbone structure from nmr PMID: 11885984
- A single-nucleotide substitution, c.382C-->T in UBE2A, led to a premature UAG stop codon (Q128X). This is the first description of a mutation in a ubiquitin-conjugating enzyme gene as the cause of a human disease. PMID: 16909393
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相關疾病：Mental retardation, X-linked, syndromic, Nascimento-type (MRXSN)
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蛋白家族：Ubiquitin-conjugating enzyme family
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數據庫鏈接：
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