TUBA1B Antibody

說(shuō)明書(shū)

中文名稱：

TUBA1B兔多克隆抗體
貨號(hào)：

CSB-PA04189A0Rb
規(guī)格：

￥440
圖片：
Western blot
All lanes: TUBA1B antibody at 12 μg/ml
Lane 1: Mouse brain tissue
Lane 2: Mouse liver tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 51, 38 kDa
Observed band size: 51, 34, 75 kDa

Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA04189A0Rb at dilution of 1:100

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA04189A0Rb at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA04189A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
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靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) TUBA1B Polyclonal antibody
Uniprot No.：

P68363
基因名：

TUBA1B
別名：

ta 2b antibody; Alpha tubulin antibody; Alpha-tubulin ubiquitous antibody; beta Ib tubulin antibody; CDCBM5 antibody; CDCBM6 antibody; fd02b12 antibody; K ALPHA 1 antibody; M40 antibody; OK/SW-cl.56 antibody; TBA1B_HUMAN antibody; TUBA1B antibody; TUBB1 antibody; TUBB2 antibody; TUBB5 antibody; tubulin alpha 1b antibody; Tubulin alpha-1B chain antibody; Tubulin alpha-ubiquitous chain antibody; Tubulin beta 1b antibody; Tubulin beta 2A antibody; tubulin beta 2A class IIa antibody; Tubulin beta antibody; tubulin beta chain antibody; tubulin beta class I antibody; tubulin beta-1 chain antibody; tubulin beta-2A chain antibody; tubulin beta-5 chain antibody; Tubulin K-alpha-1 antibody; tubulin; alpha; ubiquitous antibody; tubulin; beta 2A class IIa antibody; tubulin; beta polypeptide 2 antibody; tubulin; beta polypeptide antibody; tubulin; beta; class IIA antibody; wu:fd02b12 antibody; zgc:55461 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human, Mouse
免疫原：

Recombinant Human Tubulin alpha-1B chain protein (29-310AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，TUBA1B Antibody (CSB-PA04189A0Rb)，的標(biāo)記方式是Non-conjugated。對(duì)于TUBA1B Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA04189B0Rb	TUBA1B Antibody, HRP conjugated	ELISA
FITC	CSB-PA04189C0Rb	TUBA1B Antibody, FITC conjugated
Biotin	CSB-PA04189D0Rb	TUBA1B Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
基因功能參考文獻(xiàn)：
1. Data show that retinal endothelial cells (HREC) treated with low molecular weight fraction of commercial 5% human serum albumin (LMWF5A) exhibit a rapid increase in the amount and distribution of acetylated alpha-tubulin. PMID: 27613088
2. The C-terminal tail from the tubulin beta I isotype, but not the beta III isotype, formed contacts in the putative binding site of a recently discovered antineoplastic peptide that disrupts microtubule formation in glioma cells. PMID: 28290671
3. TUBA1B/ESR1 gene interaction might play pivotal roles in the occurrence and development of Postmenopausal Osteoporosis. PMID: 26676054
4. Taken together our data provide valuable information regarding the interaction of CK1delta and a-tubulin and a novel approach for the development of pharmacological tools to inhibit proliferation of cancer cells. PMID: 26996302
5. Results suggest that lithium chloride (LiCl) treatments activate alpha-tubulin N-acetyltransferase 1 (alphaTAT1) by the inhibition of glycogen synthase kinase 3 beta (GSK-3beta) and promote the alpha-tubulin acetylation, and then elongate the primary cilia. PMID: 24760594
6. NAD-dependent regulation of alpha-tubulin acetylation is mediated by SIRT2. PMID: 24814981
7. Data indicate that the derivatives exhibited much better potency to inhibit tubulin polymerization but a decreased activity to inhibit Hsp27 chaperone function. PMID: 23767669
8. Increased TUBA1B expression is associated with poor overall survival in hepatocellular carcinoma. PMID: 23625295
9. ARHGAP21 is a Rho-GAP involved in cell-cell junction remodeling that affects migration and EMT through alpha-tubulin interaction and acetylation PMID: 23235160
10. TQ induced a concentration- and time-dependent degradation of alpha/beta tubulin in both cancer cell types. PMID: 21881916
11. the ethyl acetate extract of Lactuca sativa induced HL-60 cell death, which correlated with the acetylation of alpha-tubulin. PMID: 20204303
12. Confocal microscopic analyses showed co-localization of the TaSP protein with alpha-tubulin and reciprocal immuno-co-precipitation experiments demonstrated an association of TaSP with alpha-tubulin in vivo. PMID: 20162433
13. This protein has been found differentially expressed in the anterior cingulate cortex from patients with schizophrenia PMID: 20381070
14. increased levels in paclitaxel-resistant breast cancer cells PMID: 12054644
15. Candidate gene K-ALPHA-1 expression in malignant and non-malignant prostate tissue samples after microdissection. PMID: 17628775
16. accumulation of alpha-synuclein might contribute to the pathogenesis of PD and other Lewy body diseases by promoting alterations in parkin and tubulin solubility PMID: 18195004
17. N-terminal sequencing and blastx analysis as well as blocking with K-alpha1 tubulin-specific Ab identified the epithelial Ag as K-alpha1 tubulin[K-alpha1 tubulin] PMID: 18354170
18. These results imply that MeCP2 is involved in the regulation of neuronal alpha-tubulin and add molecular evidence that reversal of the effects of MeCP2 deficiency is achievable PMID: 19174478
19. Increased expression of centrosomal TUBA1B in atypical ductal hyperplasia and carcinoma of the breast is reported. PMID: 19215229
20. alpha-tubulin interacted with ARL7. PMID: 19409876
21. This protein has been found differentially expressed in the Wernicke's Area from patients with schizophrenia. PMID: 19405953
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亞細(xì)胞定位：

Cytoplasm, cytoskeleton.
蛋白家族：

Tubulin family
數(shù)據(jù)庫(kù)鏈接：

HGNC: 18809

OMIM: 602530

KEGG: hsa:10376

STRING: 9606.ENSP00000336799

UniGene: Hs.524390

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