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貨期:
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用途:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
基因功能參考文獻(xiàn):
Data show that retinal endothelial cells (HREC) treated with low molecular weight fraction of commercial 5% human serum albumin (LMWF5A) exhibit a rapid increase in the amount and distribution of acetylated alpha-tubulin. PMID: 27613088
The C-terminal tail from the tubulin beta I isotype, but not the beta III isotype, formed contacts in the putative binding site of a recently discovered antineoplastic peptide that disrupts microtubule formation in glioma cells. PMID: 28290671
TUBA1B/ESR1 gene interaction might play pivotal roles in the occurrence and development of Postmenopausal Osteoporosis. PMID: 26676054
Taken together our data provide valuable information regarding the interaction of CK1delta and a-tubulin and a novel approach for the development of pharmacological tools to inhibit proliferation of cancer cells. PMID: 26996302
Results suggest that lithium chloride (LiCl) treatments activate alpha-tubulin N-acetyltransferase 1 (alphaTAT1) by the inhibition of glycogen synthase kinase 3 beta (GSK-3beta) and promote the alpha-tubulin acetylation, and then elongate the primary cilia. PMID: 24760594
NAD-dependent regulation of alpha-tubulin acetylation is mediated by SIRT2. PMID: 24814981
Data indicate that the derivatives exhibited much better potency to inhibit tubulin polymerization but a decreased activity to inhibit Hsp27 chaperone function. PMID: 23767669
Increased TUBA1B expression is associated with poor overall survival in hepatocellular carcinoma. PMID: 23625295
ARHGAP21 is a Rho-GAP involved in cell-cell junction remodeling that affects migration and EMT through alpha-tubulin interaction and acetylation PMID: 23235160
TQ induced a concentration- and time-dependent degradation of alpha/beta tubulin in both cancer cell types. PMID: 21881916
the ethyl acetate extract of Lactuca sativa induced HL-60 cell death, which correlated with the acetylation of alpha-tubulin. PMID: 20204303
Confocal microscopic analyses showed co-localization of the TaSP protein with alpha-tubulin and reciprocal immuno-co-precipitation experiments demonstrated an association of TaSP with alpha-tubulin in vivo. PMID: 20162433
This protein has been found differentially expressed in the anterior cingulate cortex from patients with schizophrenia PMID: 20381070
increased levels in paclitaxel-resistant breast cancer cells PMID: 12054644
Candidate gene K-ALPHA-1 expression in malignant and non-malignant prostate tissue samples after microdissection. PMID: 17628775
accumulation of alpha-synuclein might contribute to the pathogenesis of PD and other Lewy body diseases by promoting alterations in parkin and tubulin solubility PMID: 18195004
N-terminal sequencing and blastx analysis as well as blocking with K-alpha1 tubulin-specific Ab identified the epithelial Ag as K-alpha1 tubulin[K-alpha1 tubulin] PMID: 18354170
These results imply that MeCP2 is involved in the regulation of neuronal alpha-tubulin and add molecular evidence that reversal of the effects of MeCP2 deficiency is achievable PMID: 19174478
Increased expression of centrosomal TUBA1B in atypical ductal hyperplasia and carcinoma of the breast is reported. PMID: 19215229