TRIM29 Antibody

說明書

中文名稱：

TRIM29兔多克隆抗體
貨號：

CSB-PA618875ESR2HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA618875ESR2HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TRIM29 Polyclonal antibody
Uniprot No.：

Q14134
基因名：

TRIM29
別名：

Ataxia telangiectasia group D associated protein antibody; Ataxia telangiectasia group D-associated protein antibody; ATDC antibody; FLJ36085 antibody; TRI29_HUMAN antibody; TRIM 29 antibody; TRIM29 antibody; Tripartite motif containing 29 antibody; Tripartite motif containing protein 29 antibody; Tripartite motif protein 29 antibody; Tripartite motif protein TRIM29 antibody; Tripartite motif-containing protein 29 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Tripartite motif-containing protein 29 protein (309-588AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
基因功能參考文獻：
1. decreased expression of miR-122 and increased expression of TRIM29 was significantly associated with poor prognosis in patients with NPC. PMID: 29693120
2. Ectopic expression of TRIM29 potentially contributes to metastasis and poor prognosis in patients with osteosarcoma. PMID: 28731167
3. Knockdown of tripartite motif-containing 29 protein (TRIM29) enhanced the production of type I interferon in human and mouse dendritic cells by up to fourfold in response to intracellular herpes simplex virus. PMID: 29038422
4. the current study demonstrated that TRIM29 upregulates cyclin and Bcl family proteins level to facilitate malignant cell growth and inhibit drug-induced apoptosis in bladder cancer, possibly through PKC-NF-kappaB signaling pathways. PMID: 26987391
5. High TRIM29 expression is associated with metastasis of nasopharyngeal carcinoma. PMID: 26872369
6. Data show that TRIM29 promotes tumor progression by activating Wnt/beta-Catenin signaling. PMID: 27081037
7. This study establishes TRIM29 as a hypoxia-induced tumor suppressor gene and provides a novel molecular mechanism for ATM-dependent breast cancer suppression. PMID: 27535224
8. Upregulation of TRIM29 is associated with thyroid cancer. PMID: 28098872
9. miR-761 acts as an oncogene in triple-negative breast cancer. This mode of action can, at least partially, be ascribed to the down-regulation of its target TRIM29. PMID: 28054302
10. Silencing of TRIM29 significantly inhibited the migration and invasion ability of CRC cells. PMID: 27430345
11. Findings established a role for ATDC/TRIM29 as a robust pathogenic driver of bladder cancer development, identified downstream effector pathways, and implicated ATDC as a candidate biomarker and therapeutic target. PMID: 26471361
12. define a novel function for ATDC in the RNF8-mediated DNA damage response and implicate RNF8 binding as a key determinant of the radioprotective function of ATDC PMID: 26381412
13. Results suggest that TRIM29 functions as an oncogene in gastric cancer and is regulated by miR-185. PMID: 26191199
14. TRIM29 functions as a scaffold protein to assemble DNA repair proteins into chromatin followed by efficient activation of DNA damage response. PMID: 26095369
15. These findings suggest that TRIM29 regulates the p63-mediated pathway and the behavior of cervical cancer cells. PMID: 26071105
16. Down-regulation of ATDC inhibits the growth and proliferation of esophageal carcinoma cells. PMID: 25491629
17. TRIM29 may be useful marker for distinguishing prostate cancers from benign tissues PMID: 24485335
18. TWIST1 inhibited TRIM29 promoter activity. PMID: 24950909
19. TRIM29 promotes tumor progression and may be a novel prognostic marker for pancreatic ductal adenocarcinoma. PMID: 24864129
20. Down-regulation of TRIM29 inhibited tumor cell proliferation in vitro. PMID: 24078150
21. ATDC mRNA and protein expression were significantly higher in esophageal squamous cell carcinoma tissue than in matched noncancerous tissues. PMID: 23020249
22. Ataxia-telangiectasia group D-associated gene (ATDC) mediates resistance to ionizing radiation. PMID: 24469230
23. The expressions of TrkB and TRIM29 are correlated with lymph node metastasis in gastric cancer. PMID: 22490895
24. The interaction between TRIM29 and beta-catenin may participate in the development of lung squamous cell carcinoma. PMID: 22721621
25. results suggest that loss of TRIM29 expression in normal breast luminal cells can contribute to malignant transformation and lead to progression of ER+ breast cancer in premenopausal women. PMID: 22138580
26. Histone deacetylase 9 (HDAC9) regulates the functions of the ATDC (TRIM29) protein PMID: 20947501
27. TRIM29 allows keratinocytes to enter a protective alternative differentiation process rather than die massively after stress. PMID: 20454669
28. ATDC increases cell proliferation via inhibition of p53 nuclear activities. PMID: 20368352
29. suppressed ATDC expression is associated with malignant phenotype. PMID: 16890201
30. TRIM29 is upregulated after radical prostatectomy for prostatic neoplasms. PMID: 17448597
31. ATDC was found to stabilize beta-catenin via ATDC-induced effects on the Disheveled-2 protein, a negative regulator of glycogen synthase kinase 3beta in the Wnt/beta-catenin signaling pathway. PMID: 19249679
32. the percentage of lung carcinoma patients remaining unclassifiable by TTF-1/TP63 was twice that of the five-antibody (TRIM29, CEACAM5, SLC7A5, MUC1, and CK5/6) test PMID: 19430419
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亞細胞定位：

Cytoplasm. Lysosome. Note=Colocalizes with intermediate filaments.
組織特異性：

Expressed in placenta, prostate and thymus.
數據庫鏈接：

HGNC: 17274

OMIM: 610658

KEGG: hsa:23650

STRING: 9606.ENSP00000343129

UniGene: Hs.504115

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