TRIM29 Antibody
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中文名稱：TRIM29兔多克隆抗體
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貨號：CSB-PA289988
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA289988(TRIM29 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA289988(TRIM29 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200) -
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: HT29 cells, Primary antibody: CSB-PA289988(TRIM29 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
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其他：
產品詳情
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Uniprot No.：
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基因名：TRIM29
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別名：Ataxia telangiectasia group D associated protein antibody; Ataxia telangiectasia group D-associated protein antibody; ATDC antibody; FLJ36085 antibody; TRI29_HUMAN antibody; TRIM 29 antibody; TRIM29 antibody; Tripartite motif containing 29 antibody; Tripartite motif containing protein 29 antibody; Tripartite motif protein 29 antibody; Tripartite motif protein TRIM29 antibody; Tripartite motif-containing protein 29 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse
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免疫原：Fusion protein of Human TRIM29
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,WB,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:5000 WB 1:500-1:2000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
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基因功能參考文獻：
- decreased expression of miR-122 and increased expression of TRIM29 was significantly associated with poor prognosis in patients with NPC. PMID: 29693120
- Ectopic expression of TRIM29 potentially contributes to metastasis and poor prognosis in patients with osteosarcoma. PMID: 28731167
- Knockdown of tripartite motif-containing 29 protein (TRIM29) enhanced the production of type I interferon in human and mouse dendritic cells by up to fourfold in response to intracellular herpes simplex virus. PMID: 29038422
- the current study demonstrated that TRIM29 upregulates cyclin and Bcl family proteins level to facilitate malignant cell growth and inhibit drug-induced apoptosis in bladder cancer, possibly through PKC-NF-kappaB signaling pathways. PMID: 26987391
- High TRIM29 expression is associated with metastasis of nasopharyngeal carcinoma. PMID: 26872369
- Data show that TRIM29 promotes tumor progression by activating Wnt/beta-Catenin signaling. PMID: 27081037
- This study establishes TRIM29 as a hypoxia-induced tumor suppressor gene and provides a novel molecular mechanism for ATM-dependent breast cancer suppression. PMID: 27535224
- Upregulation of TRIM29 is associated with thyroid cancer. PMID: 28098872
- miR-761 acts as an oncogene in triple-negative breast cancer. This mode of action can, at least partially, be ascribed to the down-regulation of its target TRIM29. PMID: 28054302
- Silencing of TRIM29 significantly inhibited the migration and invasion ability of CRC cells. PMID: 27430345
- Findings established a role for ATDC/TRIM29 as a robust pathogenic driver of bladder cancer development, identified downstream effector pathways, and implicated ATDC as a candidate biomarker and therapeutic target. PMID: 26471361
- define a novel function for ATDC in the RNF8-mediated DNA damage response and implicate RNF8 binding as a key determinant of the radioprotective function of ATDC PMID: 26381412
- Results suggest that TRIM29 functions as an oncogene in gastric cancer and is regulated by miR-185. PMID: 26191199
- TRIM29 functions as a scaffold protein to assemble DNA repair proteins into chromatin followed by efficient activation of DNA damage response. PMID: 26095369
- These findings suggest that TRIM29 regulates the p63-mediated pathway and the behavior of cervical cancer cells. PMID: 26071105
- Down-regulation of ATDC inhibits the growth and proliferation of esophageal carcinoma cells. PMID: 25491629
- TRIM29 may be useful marker for distinguishing prostate cancers from benign tissues PMID: 24485335
- TWIST1 inhibited TRIM29 promoter activity. PMID: 24950909
- TRIM29 promotes tumor progression and may be a novel prognostic marker for pancreatic ductal adenocarcinoma. PMID: 24864129
- Down-regulation of TRIM29 inhibited tumor cell proliferation in vitro. PMID: 24078150
- ATDC mRNA and protein expression were significantly higher in esophageal squamous cell carcinoma tissue than in matched noncancerous tissues. PMID: 23020249
- Ataxia-telangiectasia group D-associated gene (ATDC) mediates resistance to ionizing radiation. PMID: 24469230
- The expressions of TrkB and TRIM29 are correlated with lymph node metastasis in gastric cancer. PMID: 22490895
- The interaction between TRIM29 and beta-catenin may participate in the development of lung squamous cell carcinoma. PMID: 22721621
- results suggest that loss of TRIM29 expression in normal breast luminal cells can contribute to malignant transformation and lead to progression of ER+ breast cancer in premenopausal women. PMID: 22138580
- Histone deacetylase 9 (HDAC9) regulates the functions of the ATDC (TRIM29) protein PMID: 20947501
- TRIM29 allows keratinocytes to enter a protective alternative differentiation process rather than die massively after stress. PMID: 20454669
- ATDC increases cell proliferation via inhibition of p53 nuclear activities. PMID: 20368352
- suppressed ATDC expression is associated with malignant phenotype. PMID: 16890201
- TRIM29 is upregulated after radical prostatectomy for prostatic neoplasms. PMID: 17448597
- ATDC was found to stabilize beta-catenin via ATDC-induced effects on the Disheveled-2 protein, a negative regulator of glycogen synthase kinase 3beta in the Wnt/beta-catenin signaling pathway. PMID: 19249679
- the percentage of lung carcinoma patients remaining unclassifiable by TTF-1/TP63 was twice that of the five-antibody (TRIM29, CEACAM5, SLC7A5, MUC1, and CK5/6) test PMID: 19430419
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亞細胞定位：Cytoplasm. Lysosome. Note=Colocalizes with intermediate filaments.
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組織特異性：Expressed in placenta, prostate and thymus.
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數據庫鏈接：
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