TMSB10 Antibody
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中文名稱：TMSB10兔多克隆抗體
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貨號：CSB-PA937695
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA937695(TMSB10 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA937695(TMSB10 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
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其他：
產品詳情
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Uniprot No.：
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基因名：TMSB10
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別名：MIG 12 antibody; MIG12 antibody; Migration inducing gene 12 antibody; Migration inducing protein 12 antibody; Ptmb10 antibody; TB 10 antibody; TB10 antibody; Thyb 10 antibody; Thyb10 antibody; Thymosin beta-10 antibody; Tmsb10 antibody; TYB10_HUMAN antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthetic peptide of Human TMSB10
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:10000 IHC 1:30-1:150 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
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基因功能參考文獻：
- TMSB10 may hold promise as a minimally invasive serum cancer biomarker for the diagnosis of breast cancer and a potential therapeutic target which will facilitate the development of a novel therapeutic strategy against breast cancer. PMID: 28179017
- High expression of thymosin beta 10 is associated with hepatocellular carcinoma. PMID: 25037578
- High expression levels of TMSB10 correlated with lymphatic metasttases in papillary thyroid carcinoma, especially in the central neck region. PMID: 24974154
- Regarding HCC, Tbeta4 reactivity was detected in 7/23 cases (30%) and Tbeta10 reactivity in 22/23 (97%) cases analyzed, adding HCC to human cancers that express these beta-thymosins. PMID: 24704991
- Low expression of Tbeta10 is associated with metastatic phenotype of CCA in vitro and in vivo. PMID: 24053380
- The results show, for the first time, a strong expression of thymosin beta 10 in the human salivary glands during the initial phases of the physiological development, present at the 13th week of gestation, and suggesting a role for the peptide in the salivary glands' organogenesis. PMID: 21733645
- Thymosin beta10 expression driven by the human TERT promoter induces ovarian cancer-specific apoptosis through ROS production. PMID: 22623951
- Amplification of thymosin beta 10 is associated with metastatic and aggressive papillary thyroid carcinomas. PMID: 22161024
- hypomethylation of the promoter is not associated with its overexpression in non-small cell lung cancer PMID: 22038593
- Describe beta-thymosins in bronchoalveolar lavage fluid and their possible involvement in the pathogenesis of scleroderma lung disease. PMID: 21314931
- The expression of Tbeta10 in the human kidney during the initial phases of its physiological development, mainly restricted in the proximal and the distal tubuli. PMID: 20836742
- TB10 plays a critical role in the regulation of anchorage-independent growth and assembly of actin filaments. PMID: 12481941
- Introduction of E-Tmod cDNA into a tumor cell line reverses TB10 mediated apoptosis and restored actin architectures. PMID: 14741341
- TB10 has a role in progression of human thyroid carcinomas, particularly in the anaplastic histotypes PMID: 15254683
- Inhibition of Ras signal transduction by thymosin beta(10) results in antiangiogenic and antitumor effects, suggesting that thymosin beta(10) may be valuable in anticancer therapy. PMID: 15665289
- results strongly suggest that Thr20 is specifically required for actin sequestration by TB10 in ovarian cancer cells PMID: 16012174
- the distribution of staining for thymosin beta10 was inverse of staining for F-actin. These data support a physiological role for thymosin beta10 in sequestration of G-actin as well as in cancer cell motility. PMID: 16786322
- Expression of TB10 and its role in non-small cell lung cancer are reported. PMID: 18789485
- Thymosin beta-10 is aberrantly expressed in pancreatic cancer and induces JNK activation. PMID: 19194824
- outlines for the first time that salivary glands during foetal life express and secrete peptides such as beta-thymosins probably involved in the development of the oral cavity and its annexes PMID: 19337364
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亞細胞定位：Cytoplasm, cytoskeleton.
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蛋白家族：Thymosin beta family
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數據庫鏈接：
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