TMSB10 Antibody

說明書

中文名稱：

TMSB10兔多克隆抗體
貨號：

CSB-PA274264
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA274264(TMSB10 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

產品詳情
產品評價
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靶點詳情

產品詳情

Uniprot No.：

P63313
基因名：

TMSB10
別名：

MIG 12 antibody; MIG12 antibody; Migration inducing gene 12 antibody; Migration inducing protein 12 antibody; Ptmb10 antibody; TB 10 antibody; TB10 antibody; Thyb 10 antibody; Thyb10 antibody; Thymosin beta-10 antibody; Tmsb10 antibody; TYB10_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthetic peptide of Human TMSB10
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:10000
IHC	1:30-1:150

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
基因功能參考文獻：
1. TMSB10 may hold promise as a minimally invasive serum cancer biomarker for the diagnosis of breast cancer and a potential therapeutic target which will facilitate the development of a novel therapeutic strategy against breast cancer. PMID: 28179017
2. High expression of thymosin beta 10 is associated with hepatocellular carcinoma. PMID: 25037578
3. High expression levels of TMSB10 correlated with lymphatic metasttases in papillary thyroid carcinoma, especially in the central neck region. PMID: 24974154
4. Regarding HCC, Tbeta4 reactivity was detected in 7/23 cases (30%) and Tbeta10 reactivity in 22/23 (97%) cases analyzed, adding HCC to human cancers that express these beta-thymosins. PMID: 24704991
5. Low expression of Tbeta10 is associated with metastatic phenotype of CCA in vitro and in vivo. PMID: 24053380
6. The results show, for the first time, a strong expression of thymosin beta 10 in the human salivary glands during the initial phases of the physiological development, present at the 13th week of gestation, and suggesting a role for the peptide in the salivary glands' organogenesis. PMID: 21733645
7. Thymosin beta10 expression driven by the human TERT promoter induces ovarian cancer-specific apoptosis through ROS production. PMID: 22623951
8. Amplification of thymosin beta 10 is associated with metastatic and aggressive papillary thyroid carcinomas. PMID: 22161024
9. hypomethylation of the promoter is not associated with its overexpression in non-small cell lung cancer PMID: 22038593
10. Describe beta-thymosins in bronchoalveolar lavage fluid and their possible involvement in the pathogenesis of scleroderma lung disease. PMID: 21314931
11. The expression of Tbeta10 in the human kidney during the initial phases of its physiological development, mainly restricted in the proximal and the distal tubuli. PMID: 20836742
12. TB10 plays a critical role in the regulation of anchorage-independent growth and assembly of actin filaments. PMID: 12481941
13. Introduction of E-Tmod cDNA into a tumor cell line reverses TB10 mediated apoptosis and restored actin architectures. PMID: 14741341
14. TB10 has a role in progression of human thyroid carcinomas, particularly in the anaplastic histotypes PMID: 15254683
15. Inhibition of Ras signal transduction by thymosin beta(10) results in antiangiogenic and antitumor effects, suggesting that thymosin beta(10) may be valuable in anticancer therapy. PMID: 15665289
16. results strongly suggest that Thr20 is specifically required for actin sequestration by TB10 in ovarian cancer cells PMID: 16012174
17. the distribution of staining for thymosin beta10 was inverse of staining for F-actin. These data support a physiological role for thymosin beta10 in sequestration of G-actin as well as in cancer cell motility. PMID: 16786322
18. Expression of TB10 and its role in non-small cell lung cancer are reported. PMID: 18789485
19. Thymosin beta-10 is aberrantly expressed in pancreatic cancer and induces JNK activation. PMID: 19194824
20. outlines for the first time that salivary glands during foetal life express and secrete peptides such as beta-thymosins probably involved in the development of the oral cavity and its annexes PMID: 19337364
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亞細胞定位：

Cytoplasm, cytoskeleton.
蛋白家族：

Thymosin beta family
數據庫鏈接：

HGNC: 11879

OMIM: 188399

KEGG: hsa:9168

STRING: 9606.ENSP00000233143

UniGene: Hs.446574

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