TBC1D4 Antibody, Biotin conjugated
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中文名稱：TBC1D4兔多克隆抗體, Biotin偶聯(lián)
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貨號：CSB-PA023218LD01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) TBC1D4 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：Acrg embryonic lethality (mouse) minimal region ortholog antibody; Acrg embryonic lethality minimal region ortholog antibody; Acrg embryonic lethality mouse minimal region ortholog antibody; Akt substrate of 160 kDa antibody; AS 160 antibody; AS160 antibody; BUB2 antibody; CDC16 antibody; KIAA0603 antibody; NIDDM5 antibody; TBC (Tre 2 BUB2 CDC16) domain containing protein antibody; TBC Tre 2 BUB2 CDC16 domain containing protein antibody; TBC1 D4 antibody; TBC1 domain family member 4 antibody; Tbc1d4 antibody; TBCD4_HUMAN antibody; Tre-2 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human TBC1 domain family member 4 protein (1-94AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.
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基因功能參考文獻(xiàn)：
- C-terminal region (CTR) region is largely alpha-helical and mediates TBC1D4 RabGAP dimerization PMID: 28545963
- Disruption of TBC1D4 is common among North American Inuit, resulting in exclusively elevated postprandial glucose. This leads to underdiagnosis of type 2 diabetes, unless an OGTT is performed. PMID: 27561922
- AS160 regulates glucose-independent eukaryotic cell proliferation through p21-dependent control of the cell cycle. PMID: 27152871
- AS160 and TBC1D1 phosphorylations were evident 30 min after exercise. PMID: 24876356
- homozygous carriers of a nonsense p.Arg684Ter variant have markedly higher concentrations of plasma glucose and serum insulin 2 hours after an oral glucose load compared with individuals with other genotypes PMID: 25043022
- Findings suggest that a dampening of insulin-induced phosphorylation of AS160 on specific sites in skeletal muscle contributes to the insulin resistance evident in a sedentary aging population PMID: 23801578
- insulin resistance in muscles from healthy individuals is associated with suppression of site-specific phosphorylation of AS160 PMID: 22028408
- AS160 interacts with the large cytoplasmic NP domain of the alpha-subunit of the Na(+),K(+)-ATPase. AMP-stimulated protein kinase (AMPK) and AS160 participate in a common pathway to modulate the cell surface expression of the Na(+),K(+)-ATPase. PMID: 20943949
- Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation. PMID: 21454505
- AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane PMID: 21454690
- Impaired insulin-induced site-specific TBC1D4 phosphorylation may contribute to skeletal muscle insulin resistance in type 2 diabetes. PMID: 20938636
- results show AS160 phosphorylation level is frequently increased in breast cancer; results implicate a possible role of AS160 in breast tumorigenesis and suggest that p-AS160 might be useful as a marker and a potential novel treatment target PMID: 20574165
- WNK1 promotes cell surface expression of glucose transporter GLUT1 by regulating a Tre-2/USP6-BUB2-Cdc16 domain family member 4 (TBC1D4)-Rab8A complex PMID: 20937822
- S711 is a novel TBC1D4 phosphorylation site regulated by AMPK in skeletal muscle. PMID: 19923418
- KIAA0603 is likely to be a Rab GAP that participates in the regulation of activated T cells in atopic dermatitis PMID: 15304337
- In this study, we determined the expression of and in vivo insulin action on AS160 in skeletal muscle of normal and type 2 diabetic patients. PMID: 15919790
- results indicate that AS160 is a Rab GAP, and suggest novel Rabs that may participate in GLUT4 translocation PMID: 15971998
- AS160 is phosphorylated in a time-dependent manner during moderate-intensity exercise. PMID: 17077344
- Regulation of AS160 and interaction with 14-3-3 in skeletal muscle are influenced by resistance exercise and insulin but do not fully explain the effect of resistance exercise on whole-body insulin action. PMID: 17369524
- Effects of endurance exercise training on insulin signaling and AS160 in human skeletal muscle PMID: 17513702
- AS160 is a common target of insulin, IGF-1, EGF, PMA and AICAR, these stimuli induce distinctive patterns of phosphorylation and 14-3-3 binding, mediated by at least four protein kinases. PMID: 17617058
- Impaired insulin signaling through Akt and AS160 in part explains insulin resistance at the molecular level in skeletal muscle in polycystic ovary syndrome. PMID: 17977950
- AS160, previously recognized as a key player in insulin signaling in skeletal muscle and adipose tissue, is also a major effector of protein kinase B/Akt signaling in the beta-cell. PMID: 18276765
- The transcript variant 2 of AS160 in contrast to full-length AS160 is a novel regulator of glucose transport that positively influences glucose-uptake rates. PMID: 18771725
- muscle TBC1D4 phosphorylation across the leg is increased during recovery following resistance exercise PMID: 18845784
- Specific phosphorylation of TBC1D4 in human skeletal muscle in response to physiological exercise-induced hyperinsulinemia. PMID: 19252894
- Prematurely truncated TBC1D4 protein tended to increase basal cell membrane GLUT4 levels (P = 0.053) and significantly reduced insulin-stimulated GLUT4 cell membrane translocation (P < 0.05). PMID: 19470471
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相關(guān)疾?。?/div>Diabetes mellitus, non-insulin-dependent, 5 (NIDDM5)亞細(xì)胞定位：Cytoplasm. Note=Isoform 2 shows a cytoplasmic perinuclear localization in a myoblastic cell line in resting and insulin-stimulated cells.組織特異性：Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland,數(shù)據(jù)庫鏈接：
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