TACC1 Antibody
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中文名稱：TACC1兔多克隆抗體
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貨號：CSB-PA050197
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規(guī)格：￥1090
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：TACC1
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別名：DKFZp686K18126 antibody; Ga 55 antibody; Ga55 antibody; Gastric cancer antigen Ga 55 antibody; Gastric cancer antigen Ga55 antibody; KIAA1103 antibody; TACC 1 antibody; Tacc1 antibody; TACC1_HUMAN antibody; Taxin 1 antibody; Taxin-1 antibody; Taxin1 antibody; Transforming acidic coiled coil containing protein 1 antibody; Transforming acidic coiled-coil-containing protein 1 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse
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免疫原：Synthesized peptide derived from the N-terminal region of Human TACC1.
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：WB, IHC, IF, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:10000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways. Might promote the nuclear localization of the receptors. Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.
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基因功能參考文獻(xiàn)：
- The correlation between TACC1 expression and HER-2-positive status indicates synergistic regulation of these two prognostic markers in gastric carcinoma patients. PMID: 25297519
- TFF3 and TACC1 over-expression in epithelial cells of surgically resected gastric cancer tissues was an independent predictor of short survival in gastric cancer patients. PMID: 24358147
- These findings provide proof and the foundation for the molecular and biological relationships of ErbB-2 and TACC1 in breast cancer. PMID: 23354013
- study reports that a small subset of glioblastoma multiforme tumors harbors oncogenic chromosomal translocations that fuse in-frame the tyrosine kinase coding domains of fibroblast growth factor receptor genes(FGFR1 or FGFR3) to the transforming acidic coiled-coil coding domains of TACC1 or TACC3; the FGFR-TACC fusion protein displays oncogenic activity PMID: 22837387
- TACC1 depletion in the cell led to decreased RARalpha and TRalpha ligand-dependent transcriptional activity and to delocalization of TR from the nucleus to the cytoplasm. PMID: 20078863
- Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells PMID: 11903063
- Down regulation of tacc1 controls mrna homeostasis in polarized cells and participates in oncogenic processes in human cancers PMID: 12165861
- REVIEW: genetics, expression, gene expression regulation, and function studies PMID: 12389629
- Splicing pattern of its mRNA is altered in stomach cancer PMID: 12547166
- TACC1 and the mitotic kinase Aurora B belong to the same complex during cytokinesis. PMID: 15064709
- Splice variants can be localized to different subcellular compartments in a cell-and tissue-specific manner. PMID: 16496324
- TACC1 and a three-gene expression signature (TACC1, NOV, and PTTG1) were identified as independent prognostic markers. PMID: 18984771
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亞細(xì)胞定位：Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody.; [Isoform 5]: Membrane; Lipid-anchor.; [Isoform 10]: Cytoplasm.
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蛋白家族：TACC family
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組織特異性：Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gast
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數(shù)據(jù)庫鏈接：
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