TACC1 Antibody

說明書

中文名稱：

TACC1兔多克隆抗體
貨號：

CSB-PA023065GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

O75410
基因名：

TACC1
別名：

DKFZp686K18126 antibody; Ga 55 antibody; Ga55 antibody; Gastric cancer antigen Ga 55 antibody; Gastric cancer antigen Ga55 antibody; KIAA1103 antibody; TACC 1 antibody; Tacc1 antibody; TACC1_HUMAN antibody; Taxin 1 antibody; Taxin-1 antibody; Taxin1 antibody; Transforming acidic coiled coil containing protein 1 antibody; Transforming acidic coiled-coil-containing protein 1 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human TACC1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways. Might promote the nuclear localization of the receptors. Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.
基因功能參考文獻：
1. The correlation between TACC1 expression and HER-2-positive status indicates synergistic regulation of these two prognostic markers in gastric carcinoma patients. PMID: 25297519
2. TFF3 and TACC1 over-expression in epithelial cells of surgically resected gastric cancer tissues was an independent predictor of short survival in gastric cancer patients. PMID: 24358147
3. These findings provide proof and the foundation for the molecular and biological relationships of ErbB-2 and TACC1 in breast cancer. PMID: 23354013
4. study reports that a small subset of glioblastoma multiforme tumors harbors oncogenic chromosomal translocations that fuse in-frame the tyrosine kinase coding domains of fibroblast growth factor receptor genes(FGFR1 or FGFR3) to the transforming acidic coiled-coil coding domains of TACC1 or TACC3; the FGFR-TACC fusion protein displays oncogenic activity PMID: 22837387
5. TACC1 depletion in the cell led to decreased RARalpha and TRalpha ligand-dependent transcriptional activity and to delocalization of TR from the nucleus to the cytoplasm. PMID: 20078863
6. Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells PMID: 11903063
7. Down regulation of tacc1 controls mrna homeostasis in polarized cells and participates in oncogenic processes in human cancers PMID: 12165861
8. REVIEW: genetics, expression, gene expression regulation, and function studies PMID: 12389629
9. Splicing pattern of its mRNA is altered in stomach cancer PMID: 12547166
10. TACC1 and the mitotic kinase Aurora B belong to the same complex during cytokinesis. PMID: 15064709
11. Splice variants can be localized to different subcellular compartments in a cell-and tissue-specific manner. PMID: 16496324
12. TACC1 and a three-gene expression signature (TACC1, NOV, and PTTG1) were identified as independent prognostic markers. PMID: 18984771
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亞細胞定位：

Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody.; [Isoform 5]: Membrane; Lipid-anchor.; [Isoform 10]: Cytoplasm.
蛋白家族：

TACC family
組織特異性：

Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gast
數據庫鏈接：

HGNC: 11522

OMIM: 605301

KEGG: hsa:6867

STRING: 9606.ENSP00000321703

UniGene: Hs.279245

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