TAB1 Antibody

說明書

中文名稱：

TAB1兔多克隆抗體
貨號：

CSB-PA958657
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA958657(TAB1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA958657(TAB1 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
其他：

產品詳情
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靶點詳情

產品詳情

Uniprot No.：

Q15750
基因名：

TAB1
別名：

2310012M03Rik antibody; 3'-Tab1 antibody; MAP3K7IP 1 antibody; MAP3K7IP1 antibody; MGC57664 antibody; Mitogen activated protein kinase kinase kinase 7 interacting protein 1 antibody; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 antibody; TAB 1 antibody; TAB1 antibody; TAB1_HUMAN antibody; TAK1 binding protein 1 antibody; TAK1-binding protein 1 antibody; TGF beta activated kinase 1 binding protein 1 antibody; TGF-beta activated kinase 1/MAP3K7 binding protein 1 antibody; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 antibody; TGF-beta-activated kinase 1-binding protein 1 antibody; Transforming growth factor beta activated kinase binding protein 1 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse
免疫原：

Fusion protein of Human TAB1
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
基因功能參考文獻：
1. High TAB1 expression is associated with colorectal cancer. PMID: 29328486
2. TAB1 was identified as a functional target of miR-134, and the expression of TAB1 was increased by the transcription factors of NF-kappaB1, c-Rel, and ELK1 via miR-134. PMID: 28206956
3. we show that IL-1 induces robust p38a activation both in the nucleus and in the cytoplasm/membrane.Following stimulation, p38a activity returns to a basal level in absence of receptor degradation. While nuclear pulse is controlled by MKP1 through a negative feedback to pp38, its basal activity is controlled by both TAB1 and MKP1 through a positive feedback loop. PMID: 27314954
4. TAK1/TAB1 expression in non-small cell lung carcinoma tissue is significantly increased and closely associated with patient clinical prognosis. PMID: 26884850
5. miR-29a repressed TAB1-mediated TIMP-1 production in dermal fibroblasts, demonstrating that miR-29a may be a therapeutic target in SSc. PMID: 25549087
6. Data indicate that mitogen-activated protein kinase (MAPK) p38 activation is triggered by AMP-activated protein kinases (AMPK) and mediated by TAB1 protein. PMID: 25151490
7. The amino acid sequence between positions 373 and 502 of TAB1 is required for TP interaction. PMID: 24462677
8. USP18 inhibits NF-kappaB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. PMID: 23825189
9. We found that endothelial TAK1 and TAB2, but not TAB1, were critically involved in vascular formation PMID: 22972987
10. TAK1 plays a critical role in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation. PMID: 22525462
11. data suggest a complex role of aa 452-457 of TAB1 in controlling p38 MAPK activity and subcellular localization and implicate these residues in TAK1- or p38 MAPK-dependent post-transcriptional control of gene expression PMID: 22216226
12. Phosphorylation and polyubiquitination of TAK1 are necessary for activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus vGPCR. PMID: 21159881
13. Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20805296
14. Co-expression of TAK1 and TAB1 resulted in a functional and active TAK1-TAB1 complex capable of directly activating full-length heterotrimeric mammalian AMP-activated protein kinase (AMPK) in vitro. PMID: 20538596
15. interaction with p38alpha leads to autophosphorylation and activation of p38alpha PMID: 11847341
16. The TAK1-TAB1 fusion protein is a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways PMID: 12372426
17. TauAlphaBeta1beta is involved in regulating p38alpha activity in physiological conditions PMID: 12429732
18. These results suggest that the TAK1-NLK MAPK cascade is activated by the noncanonical Wnt-5a/Ca(2+) pathway and antagonizes canonical Wnt/beta-catenin signaling. PMID: 12482967
19. characterized the molecular mechanisms of cellular stress-induced TAK1 activation, focusing mainly on the phosphorylation of TAK1 at Thr-187 and Ser-192 in the activation loop; TAB1 and TAB2 were differentially involved in the phosphorylation of TAK1 PMID: 15590691
20. Determinants that control the specific interactions between TAB1 and MAPK14 are identified. PMID: 16648477
21. The protein phosphatase 2C alpha fold is conserved in TAB1(a TAK1 regulatory subunit) but some AAs needed for dual metal-binding & catalysis are missing. It is a pseudophosphatase, & may bind/regulate access to phosphorylated AAs on downstream substrates. PMID: 16879102
22. a TAB1:TAK1:IKK beta:NF-kappaB signaling axis forms aberrantly in breast cancer cells and, consequently, enables oncogenic signaling by TGF-beta PMID: 18316610
23. TAB4 binds TAK1 and polyubiquitin chains to promote specific sites of phosphorylation in TAK1-TAB1, which activates IKK signaling to NF-kappaB. PMID: 18456659
24. periostin is involved in the suppression of cell invasiveness via the TAB1/TAK1 signaling pathway. PMID: 19578758
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組織特異性：

Ubiquitous.
數據庫鏈接：

HGNC: 18157

OMIM: 602615

KEGG: hsa:10454

STRING: 9606.ENSP00000216160

UniGene: Hs.507681

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