TAB1 Antibody
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中文名稱：TAB1兔多克隆抗體
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貨號：CSB-PA013430GA01HU
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規格：￥3,900
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：2310012M03Rik antibody; 3'-Tab1 antibody; MAP3K7IP 1 antibody; MAP3K7IP1 antibody; MGC57664 antibody; Mitogen activated protein kinase kinase kinase 7 interacting protein 1 antibody; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 antibody; TAB 1 antibody; TAB1 antibody; TAB1_HUMAN antibody; TAK1 binding protein 1 antibody; TAK1-binding protein 1 antibody; TGF beta activated kinase 1 binding protein 1 antibody; TGF-beta activated kinase 1/MAP3K7 binding protein 1 antibody; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 antibody; TGF-beta-activated kinase 1-binding protein 1 antibody; Transforming growth factor beta activated kinase binding protein 1 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Human MAP3K7IP1
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免疫原種屬：Homo sapiens (Human)
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抗體亞型：IgG
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純化方式：Antigen Affinity purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產品提供形式：Liquid
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應用范圍：ELISA,WB
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.
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基因功能參考文獻：
- High TAB1 expression is associated with colorectal cancer. PMID: 29328486
- TAB1 was identified as a functional target of miR-134, and the expression of TAB1 was increased by the transcription factors of NF-kappaB1, c-Rel, and ELK1 via miR-134. PMID: 28206956
- we show that IL-1 induces robust p38a activation both in the nucleus and in the cytoplasm/membrane.Following stimulation, p38a activity returns to a basal level in absence of receptor degradation. While nuclear pulse is controlled by MKP1 through a negative feedback to pp38, its basal activity is controlled by both TAB1 and MKP1 through a positive feedback loop. PMID: 27314954
- TAK1/TAB1 expression in non-small cell lung carcinoma tissue is significantly increased and closely associated with patient clinical prognosis. PMID: 26884850
- miR-29a repressed TAB1-mediated TIMP-1 production in dermal fibroblasts, demonstrating that miR-29a may be a therapeutic target in SSc. PMID: 25549087
- Data indicate that mitogen-activated protein kinase (MAPK) p38 activation is triggered by AMP-activated protein kinases (AMPK) and mediated by TAB1 protein. PMID: 25151490
- The amino acid sequence between positions 373 and 502 of TAB1 is required for TP interaction. PMID: 24462677
- USP18 inhibits NF-kappaB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. PMID: 23825189
- We found that endothelial TAK1 and TAB2, but not TAB1, were critically involved in vascular formation PMID: 22972987
- TAK1 plays a critical role in accentuated epithelial to mesenchymal transition in obliterative bronchiolitis after lung transplantation. PMID: 22525462
- data suggest a complex role of aa 452-457 of TAB1 in controlling p38 MAPK activity and subcellular localization and implicate these residues in TAK1- or p38 MAPK-dependent post-transcriptional control of gene expression PMID: 22216226
- Phosphorylation and polyubiquitination of TAK1 are necessary for activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus vGPCR. PMID: 21159881
- Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20805296
- Co-expression of TAK1 and TAB1 resulted in a functional and active TAK1-TAB1 complex capable of directly activating full-length heterotrimeric mammalian AMP-activated protein kinase (AMPK) in vitro. PMID: 20538596
- interaction with p38alpha leads to autophosphorylation and activation of p38alpha PMID: 11847341
- The TAK1-TAB1 fusion protein is a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways PMID: 12372426
- TauAlphaBeta1beta is involved in regulating p38alpha activity in physiological conditions PMID: 12429732
- These results suggest that the TAK1-NLK MAPK cascade is activated by the noncanonical Wnt-5a/Ca(2+) pathway and antagonizes canonical Wnt/beta-catenin signaling. PMID: 12482967
- characterized the molecular mechanisms of cellular stress-induced TAK1 activation, focusing mainly on the phosphorylation of TAK1 at Thr-187 and Ser-192 in the activation loop; TAB1 and TAB2 were differentially involved in the phosphorylation of TAK1 PMID: 15590691
- Determinants that control the specific interactions between TAB1 and MAPK14 are identified. PMID: 16648477
- The protein phosphatase 2C alpha fold is conserved in TAB1(a TAK1 regulatory subunit) but some AAs needed for dual metal-binding & catalysis are missing. It is a pseudophosphatase, & may bind/regulate access to phosphorylated AAs on downstream substrates. PMID: 16879102
- a TAB1:TAK1:IKK beta:NF-kappaB signaling axis forms aberrantly in breast cancer cells and, consequently, enables oncogenic signaling by TGF-beta PMID: 18316610
- TAB4 binds TAK1 and polyubiquitin chains to promote specific sites of phosphorylation in TAK1-TAB1, which activates IKK signaling to NF-kappaB. PMID: 18456659
- periostin is involved in the suppression of cell invasiveness via the TAB1/TAK1 signaling pathway. PMID: 19578758
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