SUMF2 Antibody, FITC conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) SUMF2 Polyclonal antibody
Uniprot No.：

Q8NBJ7
基因名：

SUMF2
別名：

SUMF2 antibody; PSEC0171 antibody; UNQ1968/PRO4500 antibody; Inactive C-alpha-formylglycine-generating enzyme 2 antibody; Paralog of formylglycine-generating enzyme antibody; pFGE antibody; Sulfatase-modifying factor 2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Sulfatase-modifying factor 2 protein (26-301AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Antigen Affinity purified & Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1.
基因功能參考文獻：
1. SUMF2 interacted with IL-13 and inhibited IL-13 secretion in bronchial smooth muscle cells and lymphocytes, which was independent of IL-13 glycosylation PMID: 19739097
2. structural analysis of human pFGE by X-ray crystallography [pFGE] PMID: 15687489
3. pFGE (SUMF2) is the paralog of the Calpha-formylglycine-generating enzyme PMID: 15708861
4. SUMF2 interacts with sulphatase-modifying factor 1 to regulate sulphatase activities. PMID: 15962010
5. pFGE is retained in the ER through its C-terminal tetrapeptide PGEL, a noncanonical variant of the classic KDEL ER-retention signal. PMID: 18266766
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亞細胞定位：

Endoplasmic reticulum lumen.
蛋白家族：

Sulfatase-modifying factor family
組織特異性：

Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in kidney, liver and placenta.
數據庫鏈接：

HGNC: 20415

OMIM: 607940

KEGG: hsa:25870

STRING: 9606.ENSP00000341938

UniGene: Hs.279696

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